Lance A. Riley

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Skeletal muscle is a major contributor to whole-body metabolism as it serves as a depot for both glucose and amino acids, and is a highly metabolically active tissue. Within skeletal muscle exists an intrinsic molecular clock mechanism that regulates the timing of physiological processes. A key function of the clock is to regulate the timing of metabolic(More)
KEY POINTS The endogenous molecular clock in skeletal muscle is necessary for maintenance of phenotype and function. Loss of Bmal1 solely from adult skeletal muscle (iMSBmal1(-/-) ) results in reductions in specific tension, increased oxidative fibre type and increased muscle fibrosis with no change in feeding or activity. Disruption of the molecular clock(More)
PURPOSE OF REVIEW This review summarizes what has been learned about the interaction between skeletal muscle and bone from mouse models in which BMAL1, a core molecular clock protein has been deleted. Additionally, we highlight several genes which change following loss of BMAL1. The protein products from these genes are secreted from muscle and have a known(More)
1. Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO, USA 2. Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, FL, USA 3. Department of Biology, University of Missouri –St. Louis, St. Louis, MO, USA 4. Institute for Translational Medicine and(More)
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