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Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease in children, and one of the major causes of short-term or long-term disability, and impairment of quality of life in… Continue Reading
Microarray gene expression analysis is high-throughput method in which many different sized DNA molecules are attached to solid surface in designated spots. These molecules are used for the discovery… Continue Reading
OBJECTIVES Our aim was to assess long-term efficacy and tolerability of etanercept and infliximab in patients with JIA. METHODS This was an observational, retrospective study of 41 patients treated… Continue Reading
Introduction: Juvenile Spondyloarthropathies (jSpA) are characterized by dysregulation of the inflammatory processes and bone metabolism which may be clarified by gene expression profiles.… Continue Reading
Spondyloarthritis or spondyloarthropathy (SpA) is a multifactorial disease in which a disturbed interplay occurs between the immune system and environmental factors on a predisposing genetic… Continue Reading
The NLRP3 inflammasome is a key component of the innate immune system serving as an intracellular sensor of microbial components and cell injury. Gain-of-function mutations of the NLRP3 gene, such as… Continue Reading