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Tetrazine-Containing Amino Acid for Peptide Modification and Live Cell Labeling
The combination of tetrazine group and amino acid offered broad development prospects of the bioorthogonal labeling and peptide synthesis and showed excellent stability in biological media and might be used for cancer cell labeling.
Influence of Proline Substitution on the Bioactivity of Mammalian-Derived Antimicrobial Peptide NK-2
- Jie-xi Yan, Xiaolei Liang, Li Zhao
- Biology, ChemistryProbiotics and Antimicrobial Proteins
- 1 March 2018
It was shown that introducing proline into the primary sequence of NK-2 significantly decreased the antitumor, antibacterial, and cytotoxic effects, as well as DNA binding activity by changing the α-helical content.
NK-18, a promising antimicrobial peptide: anti-multidrug resistant leukemia cells and LPS neutralizing properties.
Analgesic properties of chimeric peptide based on morphiceptin and PFRTic-amide
Interaction of endokinin A/B and (Mpa6)-γ2-MSH-6–12 in pain regulation in mice
Effects of endokinin A/B and endokinin C/D on the antinociception properties of hemopressin in mice
Pain regulation of endokinin A/B or endokinin C/D on chimeric peptide MCRT in mice.
- Chunbo He, Junbin Gong, Lixia Yang, Hongwei Zhang, S. Dong, Lan-xia Zhou
- Biology, ChemistryCanadian journal of physiology and pharmacology
- 15 April 2016
Two reasonable hypotheses to explain the cocktail-induced analgesia are made: (1) MCRT and endomorphin-1 possibly activated different μ subtypes; and (2) picomolar EKA/B might motivate the endogenous NPFF system after NK1 activation.
The cardiovascular effects of a chimeric opioid peptide based on morphiceptin and PFRTic-NH2
Supraspinal inhibitory effects of chimeric peptide MCRT on gastrointestinal motility in mice
The study focused on the supraspinal effects of morphiceptin, PFRTic‐NH2 and MCRT on gastrointestinal motility and opioid receptor antagonists, naloxone (non‐selective), cyprodime (MOR selective) and naltrindole (DOR selective), were utilized to explore the mechanisms.
Association of cytotoxic T-lymphocyte antigen 4 gene with immune thrombocytopenia in Chinese Han children
The CTLA4 gene is suggested to correlate with ITP through its abnormal expression level instead of gene site mutation because of the autoimmune and gene etiology of ITP.