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Hepatitis B is a potentially life-threatening liver infection caused by the hepatitis B virus (HBV) and is a major global health problem. HBV is the most common serious viral infection and a leading cause of death in mainland China. Around 130 million people in China are carriers of HBV, almost a third of the people infected with HBV worldwide and about 10%(More)
Thirty-four rhizobial isolates were obtained from root nodules of four wild Desmodium species growing in Panxi, Sichuan, China. According to the combined ARDRA and IGS-RFLP (CACAI) cluster analysis, Rhizobium, Pararhizobium and Mesorhizobium isolates outnumbered Bradyrhizobium isolates. In general, the isolates representing the same species from the same(More)
A total of 54 rhizobial strains were isolated from faba bean root nodules in 21 counties of Sichuan hilly areas in China, and their symbiotic effectiveness, genetic diversity and phylogeny were assessed. Only six strains increased the shoot dry mass of the host plant significantly (P ≤ 0.05). Based on the cluster analysis of combined 16S rDNA and intergenic(More)
This study aimed to investigate whether single nucleotide polymorphisms (SNPs) in the promoter of the excision repair cross complementation group 5 (ERCC5) gene influences response to oxaliplatin-based chemotherapy. Eighty-three patients with cytologically or histologically confirmed advanced colorectal cancer (CRC), at least one measurable lesion and(More)
In the last 60 years, great progress has been made in controlling and preventing schistosomiasis in China. However, due to the ecosystem changes caused by the construction of the Three Gorges Dams and the South-north Water Conversion Project, the effects of climate change, the scarcity of a highly sensitive surveillance and response system, schistosomiasis(More)
BACKGROUND Multidrug resistance (MDR) is one of the major reasons chemotherapy-based treatments fail. Hypoxia is generally associated with tumor chemoresistance. However, the correlation between the heterodimeric hypoxia-inducible factor-1 (HIF-1) and the multidrug resistance (MDR1) gene/transporter P-glycoprotein (P-gp) remains unclear. This study aims to(More)
Hubei Province, along with four other provinces in the central and eastern China where schistosomiasis is endemic (Anhui, Hunan, Jiangsu, and Jiangxi), is located in the lake and marshland regions along the Yangtze River. High population density, large numbers of farm cattle, and huge areas of snail habitat are the main characteristics that maintain the(More)
Hepatitis B virus (HBV) infection is endemic in many parts of the world. One of the characteristics of HBV transmission is the age structure of the host population. In this paper, we propose an age-structured model for the transmission dynamics of HBV. The host population is stratified by age and is divided into six subclasses: susceptible, latently(More)
The heterohexameric origin recognition complex (ORC) has been implicated in many cellular activities, including DNA replication, transcriptional control, heterochromatin assembly, centromere and telomere function, and so on. Here, we report a new function for ORC in mediating histone methylation. Using the yeast two-hybrid system, we identify a physical(More)
In a previous study we noticed that there might be co-infections of HBV and HIV by comparing incidence rates of these two diseases in China. The comparisons between the incidence data of HBV and sexually transmitted diseases (including AIDS, HIV, syphilis and gonorrhea) in China demonstrate that sexual transmission is an important route of spread of HBV in(More)