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PURPOSE We propose a patient-specific algorithm for seizure prediction using multiple features of spectral power from electroencephalogram (EEG) and support vector machine (SVM) classification. METHODS The proposed patient-specific algorithm consists of preprocessing, feature extraction, SVM classification, and postprocessing. Preprocessing removes(More)
Visual exploration has proven to be a powerful tool for multivariate data mining and knowledge discovery. Most visualization algorithms aim to find a projection from the data space down to a visually perceivable rendering space. To reveal all of the interesting aspects of multimodal data sets living in a high-dimensional space, a hierarchical visualization(More)
In designing consumer durables such as appliances and power tools, it is important to account for variations in product performance across different usage situations and conditions. Since the specific usage of the product and the usage conditions can vary, the resultant variations in product performance also can impact consumer preferences for the product.(More)
Primary points of control in steroidogenesis are the transport of cholesterol from intracellular stores to the inner mitochondrial membrane, and the subsequent conversion of cholesterol to pregnenolone by the cholesterol side-chain cleavage enzyme (P450scc). Testosterone production has been shown to decline in Brown Norway rat Leydig cells as the rats age.(More)
We present an integrated design and marketing approach to facilitate the generation of an optimal robust set of product design alternatives to carry forward to the prototyping stage. The approach considers variability in both (i) engineering design domain, and (ii) customer preferences in marketing domain. In the design domain, the approach evaluates(More)
We assessed the neuroprotective effects of quercetin-feeding at doses of 5 and 10 mg/(kg day) on Kunming mice injected daily with D-gal (50 mg/(kg day)) by behavioral tests. Quercetin-fed mice showed higher activity upon induction by new environmental stimuli, lower anxiety and higher novelty-seeking behavior in the open field tasks, and significantly(More)
land. The authors thank the two anonymous JMR reviewers for their helpful comments and guidance. Consumers often use both objective and subjective criteria to evaluate a product. For example, power tool users may evaluate a power tool on the basis of not only its objective attributes, such as price and switch type, but also its subjective characteristics,(More)
Previous studies have shown that the ability of Brown Norway rat Leydig cells to produce testosterone declines significantly with age. To address the possible mechanism(s) by which aging Leydig cells lose steroidogenic function, we determined the effect of age on the steady-state levels of the mRNAs for the steroidogenic enzymes P450 cholesterol side-chain(More)
Product line design for consumer durables often relies on close coordination between marketing and engineering domains. Product lines that evolve as " optimal " from marketers' perspective may not be " optimal " from an engineering viewpoint, and vice versa. Although extant research has proposed sophisticated techniques to handle problems that characterize(More)
BACKGROUND Abnormal activity of STAT3 is associated with a number of human malignancies. Hsp90 plays a central role in stabilizing newly synthesized proteins and participates in maintaining the functional competency of a number of signaling transducers involved in cell growth, survival and oncogenesis, such as STAT3. Hsp90 interacts with STAT3 and(More)