Lambertus W. Bartels

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An automated method for segmenting the outer boundary of abdominal aortic aneurysms in MR images is presented. The method is based on the well known Active Shape Models (ASM), which fit a global landmark-based shape model on the basis of local boundary appearance models. The original three-dimensional ASM scheme is modified to deal with multi-spectral image(More)
BACKGROUND CONTEXT It is well known that spinal biomechanics and familial predisposition play an important role in the onset and evolution of idiopathic scoliosis. The relationship between the sagittal profile of the spine and spinal biomechanics has also been established in a number of studies. It has been suggested previously that a certain sagittal(More)
The advantage of 2D-3D image registration methods versus direct image-to-patient registration, is that these methods generally do not require user interaction (such as manual annotations), additional machinery or additional acquisition of 3D data. A variety of intensity-based similarity measures has been proposed and evaluated for different applications.(More)
OBJECTIVE To prospectively assess the safety and technical feasibility of volumetric magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU) ablation with direct skin cooling (DISC) during treatment of uterine fibroids. METHODS In this proof-of-concept study, eight patients were consecutively selected for clinical MR-HIFU ablation of uterine(More)
PURPOSE To report the first clinical experience with targeted vessel ablation during magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU) treatment of symptomatic uterine fibroids. METHODS Pretreatment T1-weighted contrast-enhanced magnetic resonance angiography was used to create a detailed map of the uterine arteries and feeding(More)
BACKGROUND Magnetic resonance (MR)-guided high-intensity focused ultrasound has emerged as a clinical option for palliative treatment of painful bone metastases, with MR thermometry (MRT) used for treatment monitoring. In this study, the general image quality of the MRT was assessed in terms of signal-to-noise ratio (SNR) and apparent temperature variation.(More)
BACKGROUND Magnetic resonance-guided high intensity focused ultrasound (MR-HIFU) has recently emerged as an effective treatment option for painful bone metastases. We describe here the first experience with volumetric MR-HIFU for palliative treatment of painful bone metastases and evaluate the technique on three levels: technical feasibility, safety, and(More)
BACKGROUND The purpose of this study is to investigate whether changes could be detected in dynamic contrast-enhanced (DCE) and intra-voxel incoherent motion (IVIM) MR parameters upon MR-guided high-intensity focused ultrasound (MR-HIFU)-induced hyperthermia in a rabbit Vx2 tumor model. METHODS Five Vx2 tumor-bearing New Zealand white rabbits were treated(More)
Background/introduction We have recently conducted a clinical phase I study to assess the safety and spatial accuracy and precision of a newly developed dedicated MR-HIFU system for breast tumor ablation. In this system the breast is placed in a water filled cup, which is surrounded by an arc of ultra-sound transducers.[1] This lateral sonication approach(More)