Lambertus J. H. van Tits

  • Citations Per Year
Learn More
Sirtuin 3 (Sirt3) is an NAD+-dependent mitochondrial deacetylase associated with superoxide dismutase 2 (SOD2)-mediated protection from oxidative stress. We have reported accelerated weight gain and impaired metabolic flexibility in atherosclerotic Sirt3 −/− mice. Oxidative stress is a hallmark of endothelial dysfunction. Yet, the role of Sirt3 in this(More)
Native LDL (nLDL) increases expression of adhesion molecules on endothelial cells through induction of Ca 2 mobilization. Ca 2 mobilization is also involved in the induction of proinflammatory cytokines, important mediators involved in atherogenesis. The aim of the study was to evaluate the capacity of nLDL to affect spontaneous and lipopolysaccharide(More)
since the discovery of human serum paraoxonase (poN1), the enzyme has been the subject of various fields of research. initially, poN1 was identified as an enzyme capable of hydrolysing organophosphate compounds, but there is a growing body of evidence that poN1 plays a role in lipid metabolism and the onset of cardiovascular disease. still, the precise(More)
Patients with familial hypercholesterolemia (FH) and patients with end-stage renal disease (ESRD) undergoing dialysis suffer from accelerated atherosclerosis. Oxidation of low-density lipoprotein (LDL) cholesterol is crucial in atherogenesis. In the present study, we determined the LDL oxidation level and oxidizability of isolated LDL of 11 male patients(More)
Chronic periaortitis is thought to result from an autoallergic reaction to oxidized low-density lipoprotein (OxLDL). No data exist on lipid profile and atherosclerotic biomarkers. We investigated circulating levels of OxLDL and of anti-OxLDL (aOxLDL) antibodies in patients with chronic periaortitis using the cross-sectional case–control study on 20 patients(More)
We investigated whether long-term a-tocopherol therapy in chronic smoking affects superoxide generating capacity of neutrophilsex vivo. To this purpose, we randomly assigned 128 male chronic smokers (37 ± 21 pack years of smoking) to treatment with placebo(n = 64) or α-tocopherol (400 IU dL-α-tocopherol daily,n = 64). After two years of therapy, we measured(More)
Objectives—Familial combined hyperlipidemia (FCH) is a common familial lipid disorder characterized by increases in plasma total cholesterol, triglyceride, and apolipoprotein B-100 levels. In light of prior metabolic and genetic research, our purpose was to ascertain whether FCH cases had significant abnormalities of plasma markers of cholesterol synthesis(More)
  • 1