The ultrasonic propulsion of rod-shaped nanomotors inside living HeLa cells is demonstrated. These nanomotors (gold rods about 300 nm in diameter and about 3 mm long) attach strongly to the external surface of the cells, and are readily internalized by incubation with the cells for periods longer than 24 h. Once inside the cells, the nanorod motors can be… (More)
The recent discovery of fuel-free propulsion of nanomotors using acoustic energy has provided a new avenue for using nanomotors in biocompatible media. Crucial to the application of nanomotors in biosensing and biomedical applications is the ability to remotely control and steer them toward targets of interest, such as specific cells and tissues. We… (More)
We measure the microvortical flows around gold nanorods propelled by ultrasound in water using polystyrene nanoparticles as optical tracers. We infer the rotational frequencies of such nanomotors assuming a hydrodynamic model of this interaction. In this way, we find that nanomotors rotate around their longitudinal axes at frequencies of up to ≈ 2.5 kHz, or… (More)
— This paper explores a new application of struc-tured illumination to determine the position of a microscope stage. Measuring stage position accurately is important for any experiment that spans multiple fields of view. The struc-tured illumination pattern is provided by a design printed on the microscope slide or cover slip that modulates the image of the… (More)
The ability to use magnets external to the body to focus therapy to deep tissue targets has remained an elusive goal in magnetic drug targeting. Researchers have hitherto been able to manipulate magnetic nanotherapeutics in vivo with nearby magnets but have remained unable to focus these therapies to targets deep within the body using magnets external to… (More)
We demonstrate magnetic metal-polymer composite microshell particles having a single nanoscale hole in the metal microshell layer. We load the surfaces of these particles with temozolomide (TMZ), a common brain cancer chemotherapeutic, and confirm loading via UV-vis spectroscopy.