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The actin-binding ERM protein Moesin binds to and stabilizes microtubules at the cell cortex
The direct interaction between the ERM protein Moesin and microtubules is required for spindle organization in metaphase and cell shape transformation after anaphase onset.
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KIF14 binds tightly to microtubules and adopts a rigor-like conformation.
The mitotic kinesin motor protein KIF14 is essential for cytokinesis during cell division and has been implicated in cerebral development and a variety of human cancers. Here we show that the mouseExpand
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Adaptive Resistance to an Inhibitor of Chromosomal Instability in Human Cancer Cells.
Karyotype diversity is a hallmark of solid tumors that contributes to intratumor heterogeneity. This diversity is generated by persistent chromosome mis-segregation associated with chromosomalExpand
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Interdomain allosteric regulation of Polo kinase by Aurora B and Map205 is required for cytokinesis
Aurora B phosphorylation of the Polo kinase activation loop disrupts its binding to Map205 and central spindle microtubules, allowing it to be recruited to the site of cytokinesis.
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Ternary complex of Kif2A-bound tandem tubulin heterodimers represents a kinesin-13-mediated microtubule depolymerization reaction intermediate
Kinesin-13 proteins are major microtubule (MT) regulatory factors that catalyze removal of tubulin subunits from MT ends. The class-specific “neck” and loop 2 regions of these motors are required forExpand
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DHTP is an allosteric inhibitor of the kinesin‐13 family of microtubule depolymerases
The kinesin‐13 family of microtubule depolymerases is a major regulator of microtubule dynamics. RNA interference‐induced knockdown studies have highlighted their importance in many cell divisionExpand
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Crystal structure of the mouse Kif14 motor domain