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— In this paper regional Input-to-State Stability (ISS) is introduced and studied in order to analyze the domain of attraction of nonlinear constrained systems with disturbances. ISS is derived by means of a non smooth ISS-Lyapunov function with an upper bound guaranteed only in a sub-region of the domain of attraction. These results are used to study the(More)
SUMMARY This paper describes a model predictive control (MPC) algorithm for the solution of a state-feedback robust control problem for discrete-time nonlinear systems. The control law is obtained through the solution of a finite-horizon dynamic game and guarantees robust stability in the face of a class of bounded disturbances and/or parameter(More)
The control of diabetes is an interdisciplinary endeavor, which includes a significant biomedical engineering component, with traditions of success beginning in the early 1960s. It began with modeling of the insulin-glucose system, and progressed to large-scale in silico experiments, and automated closed-loop control (artificial pancreas). Here, we follow(More)
Modularity plays a key role in many engineering systems, allowing for plug-and-play integration of components, enhancing flexibility and adaptability, and facilitating standardization. In the control of diabetes, i.e., the so-called "artificial pancreas," modularity allows for the step-wise introduction of (and regulatory approval for) algorithmic(More)
BACKGROUND An artificial pancreas (AP) that can be worn at home from dinner to waking up in the morning might be safe and efficient for first routine use in patients with type 1 diabetes. We assessed the effect on glucose control with use of an AP during the evening and night plus patient-managed sensor-augmented pump therapy (SAP) during the day, versus 24(More)
AIMS To test in an outpatient setting the safety and efficacy of continuous subcutaneous insulin infusion (CSII) driven by a modular model predictive control (MMPC) algorithm informed by continuous glucose monitoring (CGM) measurement. METHODS 13 patients affected by type 1 diabetes participated to a non-randomized outpatient 42-h experiment that included(More)
BACKGROUND In 2008-2009, the first multinational study was completed comparing closed-loop control (artificial pancreas) to state-of-the-art open-loop therapy in adults with type 1 diabetes mellitus (T1DM). METHODS The design of the control algorithm was done entirely in silico, i.e., using computer simulation experiments with N=300 synthetic "subjects"(More)
The latest achievements in sensor technologies for blood glucose level monitoring, pump miniaturization for insulin delivery, and the availability of portable computing devices are paving the way toward the artificial pancreas as a treatment for diabetes patients. This device encompasses a controller unit that oversees the administration of insulin(More)
BACKGROUND Closed-loop control of type 1 diabetes is receiving increasing attention due to advancement in glucose sensor and insulin pump technology. Here the function and structure of a class of control algorithms designed to exert control to range, defined as insulin treatment optimizing glycemia within a predefined target range by preventing extreme(More)