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Diabetic neuropathy is a heterogeneous group of disorders with extremely complex pathophysiology and affects both somatic and autonomic components of the nervous system. Neuropathy is the most common chronic complication of diabetes mellitus. Metabolic disruptions in the peripheral nervous system, including altered protein kinase C activity, and increased(More)
ETHNOPHARMACOLOGICAL RELEVANCE Long term hyperglycemia leads to development of complications associated with diabetes. Diabetic complications are now a global health problem without effective therapeutic approach. Hyperglycemia and oxidative stress are important components for the development of diabetic complications. Over the past few decades, herbal(More)
Diabetes mellitus is characterized by loss of glucose homeostasis; altered metabolism of glucose, proteins and lipids. Although a number of effective allopathic medicines are currently available for treatment and management of diabetes, but prevalence of side effects and higher cost poses a big challenge to the goal of pharmacotherapy. Herbs are mine of(More)
BACKGROUND Diabetic nephropathy (DN) is one of the foremost causes of mortality in diabetic patients as a result of increased urinary albumin excretion (UAE) rate and compromised renal function. INTRODUCTION Determination of increased excretion of albumin in urine chiefly attribute to the onset and progression of DN. However, due to certain limitations of(More)
1 D/O R L Gupta, Raja Cycle Colony,Street No 2,Srinagar Road Ajmer, Rajasthan Pin 305007 2 347, Ward No 9 Salavato Ka Bas Sadri, Dist Pali, Rajasthan Pin 306702 Email: drlalitkishore@gmail.com, Telephone: +919887733389 3 C/O R L Gupta, Raja Cycle Colony, Street No 2, Srinagar Road Ajmer, Rajasthan Pin 305007 4 3/75 Hanuman Bagh Colony, Nagaur Rajasthan Pin(More)
Hyperglycemia and oxidative stress are involved in the development of diabetic nephropathy (DN). This study was designed to evaluate the effect of alcohol and hydroalcohol extract of Bacopa monnieri and stigmasterol isolated from B. monnieri in the treatment of DN. Diabetes was induced in male wistar rats by streptozotocin (65 mg/kg i.p.) 15 min after(More)
The present study was aimed to evaluate the potential of petroleum ether and hydro-alcoholic extract of Linum usitatissimum (FPE and FHE) in STZ-nicotinamide induced diabetic nephropathy. GC-MS analysis of FPE revealed the presence of different fatty acids, heterocyclic compounds etc. Moreover, chromatography of FHE isolated Secoisolariciresinol(More)
INTRODUCTION To study the efficacy of holmium laser urethrotomy with intralesional injection of Santosh PGI tetra-inject (Triamcinolone, Mitomycin C, Hyaluronidase and N-acetyl cysteine) in the treatment of urethral strictures. MATERIAL AND METHODS A total of 50 patients with symptomatic urethral stricture were evaluated by clinical history, physical(More)
Diabetic nephropathy is a long-term complication of diabetes mellitus. Chronic hyperglycemia leads to the generation of reactive oxygen species leading to oxidative stress. Hyperglycemia and oxidative stress are involved in the development of diabetic nephropathy. This study was designed to evaluate the effect of homeopathic preparation of Gymnema sylvestre(More)