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PURPOSE To assess the dosimetric impact of interplay between spot-scanning proton beam and respiratory motion in intensity-modulated proton therapy (IMPT) for stage III lung cancer. METHODS Eleven patients were sampled from 112 patients with stage III nonsmall cell lung cancer to well represent the distribution of 112 patients in terms of target size and(More)
Glucose-insulin interaction in an insulin-dependent diabetic patient has been simulated using an overall model based on pharmacokinetic diagrams of insulin and glucose. Model is capable of predicting the blood glucose and insulin levels, total glucose uptake and the renal glucose excretion. The treatment strategy is based on a four-daily dose of regular(More)
PURPOSE The primary aim of this study was to evaluate the impact of the interplay effects of intensity modulated proton therapy (IMPT) plans for lung cancer in the clinical setting. The secondary aim was to explore the technique of isolayered rescanning to mitigate these interplay effects. METHODS AND MATERIALS A single-fraction 4-dimensional (4D) dynamic(More)
The purpose of this paper is twofold: (1) to examine strengths and weaknesses of recently developed optimization methods for selecting radiation treatment beam angles and (2) to propose a simple and easy-to-use hybrid framework that overcomes some of the weaknesses observed with these methods. Six optimization methods –branch and bound (BB), simulated(More)
Robust optimization of intensity-modulated proton therapy (IMPT) takes uncertainties into account during spot weight optimization and leads to dose distributions that are resilient to uncertainties. Previous studies demonstrated benefits of linear programming (LP) for IMPT in terms of delivery efficiency by considerably reducing the number of spots required(More)
PURPOSE Various robust optimization approaches have been proposed to ensure the robustness of intensity modulated proton therapy (IMPT) in the face of uncertainty. In this study, we aim to investigate the performance of three classes of robust optimization approaches regarding plan optimality and robustness. METHODS Three robust optimization models were(More)
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