Lakshmi Sangameswaran

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Microarray technology is a powerful methodology for identifying differentially expressed genes. However, when thousands of genes in a microarray data set are evaluated simultaneously by fold changes and significance tests, the probability of detecting false positives rises sharply. In this first microarray study of brachial plexus injury, we applied and(More)
Species: Mouse Locus names: Peripheral sodium channels 1 and 3 (PN 1 and PN3), alpha subunits 9 and 10 Locus symbols: Scn9a, ScnlOa Map position: Chromosome (Chr) 2:Abl-lO.3 +_ 2.0-Cchb4-9.2 +_ 2.0-Scn9a, Scn3a--4.1 +_ 1.4; Chr 9 :Gna t l -9 .8 + 2.7-ScnlOa-l.O + 0.7-Cck, Tna (Fig. 1). Method o f mapping: Two sets of genetic crosses were typed: (NFS/N x Mus(More)
Root avulsion from the spinal cord occurs in brachial plexus lesions. It is the practice to repair such injuries by transferring an intact neighbouring nerve to the distal stump of the damaged nerve; avulsed dorsal root ganglia (DRG) are removed to enable nerve transfer. Such avulsed adult human cervical DRG ( [Formula: see text] ) obtained at surgery were(More)
Alterations in sodium channel expression and function have been suggested as a key molecular event underlying the abnormal processing of pain after peripheral nerve or tissue injury. Although the relative contribution of individual sodium channel subtypes to this process is unclear, the biophysical properties of the tetrodotoxin-resistant current, mediated,(More)
The Stokes radii and the apparent molecular weights of the CHAPS or Triton X-100 solubilized benzodiazepine receptors are calculated by gel exclusion chromatography. The results suggest that the molecular receptor complex solubilized by CHAPS is much larger than the complex solubilized by Triton X-100.
The mouse autosomal recessive mutant gene weaver (wv) results in abnormalities in cerebellum, substantia nigra and testis. Although a subtracted cDNA library prepared by removing P31 (wv/wv) sequences from a P1 (wv/+) library should contain mainly nonrepetitive neonatal sequences, unfortunately, repetitive sequences still appear during screening. Two(More)
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