Lakshmi Jayashankar

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The increasing use of nonhuman primate models in biomedical research and especially in vaccine development requires the characterization of their immunoglobulin genes and corresponding products. Therefore, we sequenced, cloned and characterized the four immunoglobulin gamma chain constant region genes ( IGHG) present in baboons. These four genes were(More)
Rhesus macaques (Macaca mulatta) are extensively used in vaccine development. Macaques infected with simian immunodeficiency viruses (SIV) or simian-human immunodeficiency viruses (SHIV) are the best animal model currently available for acquired-immune-deficiency-syndrome-related studies. Recent results emphasize the importance of antibody responses in(More)
Antibodies are adaptor molecules of the immune system that link antigen recognition with the effector mechanisms responsible for antigen clearance. Several nonhuman primate species are widely used in biomedical research, especially for vaccine development and for AIDS-related studies. However, nonhuman primate antibody molecules have been characterized only(More)
Nonhuman primates are extremely valuable animal models for a variety of human diseases. However, it is now becoming evident that these models, although widely used, are still uncharacterized. The major role that nonhuman primate species play in AIDS research as well as in the testing of Ab-based therapeutics requires the full characterization of structure(More)
The age-related modulation of lymphocyte number and function was assessed in a nonhuman primate model consisting of healthy olive baboons (Papio cynocephalus anubis) of ages encompassing the entire life span of this species. The objectives of this study were to characterize an animal model of immunosenescence and to assess whether or not age should be(More)
Baboons are increasingly used as animal models in studies that require the assessment of specific antibody responses. The complete analysis of these responses includes the characterization of antibody variable region genes and their usage. Therefore, we cloned and sequenced a total of 27 immunoglobulin variable region heavy chain (IGHV) genes using cDNA(More)
3-Dimensional Quantitative Structure-Activity Relationship (3D-QSAR) study was performed to explore the binding mechanism of some Quinazoline derivatives to Aurora B Kinase. Molecular Field Analysis (MFA) and Receptor surface Analysis (RSA) methods have been carried out to derive best QSAR models. Model developed by MFA and RSA methods has an R 2(More)
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