Lakshmana Gowda Krishnappa

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The widespread use of antimicrobials has increased the occurrence of multidrug resistant microbes. The commonest mechanism of antimicrobial resistance in Enterobacteriaceae is production of β-lactamases such as metallo-β-lactamases (MBL) and extended spectrum β-lactamases (ESBL). Few studies have used a molecular approach to characterize the prevalence of(More)
The present study evaluates the synergistic effect of sulbactam/tazobactam in combination with meropenem or colistin against multidrug resistant (MDR) Acinetobacter baumannii isolated from hospitalized patients from a tertiary care hospital in Saudi Arabia. During the study period, 54 multidrug and carbapenem-resistant isolates of A. baumannii isolates were(More)
OBJECTIVE Pleural effusion is a common diagnostic and clinical problem. Neoplasms and tuberculosis are the most frequent diagnostic causes of such effusions. Conventional laboratory methods for diagnosis of such effusion are inefficient because tubercle bacilli are rarely seen in direct examinations of pleural fluid. The present study evaluates(More)
Journal of Laboratory Physicians / Jan-Jun 2014 / Vol-6 / Issue-1 64 Candida glabrata fungemia: Experience in a tertiary care center. Clin Infect Dis 2005;41:975‐81. 3. Xess I, Jain N, Hasan F, Mandal P, Banerjee U. Epidemiology of candidemia in a tertiary care centre of north India: 5‐year study. Infection 2007;35:256‐9. 4. Sanglard D, Ischer F, Monod M,(More)
In this prospective study, consecutive isolates of Klebsiella pneumoniae were tested for different mechanisms of carbapenem resistance using the modified Hodge test (MHT), Rosco Neo-Sensitabs (ROSCO). Phenylalanine arginine beta-naphthylamide assay (PABN) inhibitor-based test was done on isolates in which the mechanism of resistance was not identifiable by(More)
In recent years bacteria have shown much more potential to develop antimicrobial resistance. This mandates not only to the development of new drugs but also to the re-evaluation of already existing ones. Present study is sought to evaluate the in vitro activity of a few newer antibiotics which are not marketed in many countries at present. This study(More)
BACKGROUND Co production of 16S rRNA methylases gene and β-Lactamase gene among Enterobacteriaceae isolates conferring resistance to both therapeutic options has serious implications for clinicians worldwide. METHODS To study co existence of 16S rRNA methylases (armA, rmtA, rmtB, rmtC, rmtD, and npmA) and β-Lactamase (blaTEM-1, blaSHV-12, blaCTX-M-14)(More)
In Gram negative bacteria the signaling molecule is N-acyl homoserine lactone where carbon chain length varies depending upon the species. Signaling mechanism has effect on many gene expression regulations used to organize and coordinate their multiple virulence determinants as such the production of bioflim, virulence factors required for colonizing and(More)
Streptococcus pneumoniae causes life threatening infections and necessitate for impediment and controlling disease; to conquer this, information is needed about serotype distribution and patterns of antibiotic resistance. The present study was to determine the serotype distribution of S. pneumoniae isolated from the entire age group individual and to(More)
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