Laine Thomas

2Kenneth W Mahaffey
2James A Reiffel
2Bernard J Gersh
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O ral anticoagulation (OAC) significantly reduces the risk of stroke in patients with atrial fibrillation (AF). However, many AF patients on long-term anticoagula-tion undergo procedures that require temporary interruption of OAC. Some have advocated that patients receive short-acting anticoagulants during these temporary interruptions to " bridge " the(More)
BACKGROUND The prevalence of atrial fibrillation (AF) continues to increase; however, there are limited data describing the division of care among practitioners in the community and whether care differs depending on provider specialty. METHODS AND RESULTS Using the Outcomes Registry for Better Informed Treatment of AF (ORBIT-AF) Registry, we described(More)
Studies of clinical characteristics frequently measure covariates with a single observation. This may be a mismeasured version of the "true" phenomenon due to sources of variability like biological fluctuations and device error. Descriptive analyses and outcome models that are based on mismeasured data generally will not reflect the corresponding analyses(More)
  • Larry R Jackson, Sung Hee Kim, Jonathan P Piccini, Bernard J Gersh, Gerald V Naccarelli, James A Reiffel +8 others
  • 2016
BACKGROUND Patients with sinus node dysfunction (SND) have increased risk of atrial tachyarrhythmias, including atrial fibrillation (AF). To date, treatment patterns and outcomes of patients with SND and AF have not been well described. HYPOTHESIS Patients with SND and AF have higher risk of adverse cardiovascular outcomes. METHODS Sinus node(More)
OBJECTIVE  To determine whether the treatment effect of apixaban versus warfarin differs with increasing numbers of concomitant drugs used by patients with atrial fibrillation. DESIGN  Post hoc analysis performed in 2015 of results from ARISTOTLE (apixaban for reduction in stroke and other thromboembolic events in atrial fibrillation)-a multicentre,(More)
OBJECTIVE Atrial fibrillation (AF) often progresses from paroxysmal or persistent to more sustained forms, but the rate and predictors of AF progression in clinical practice are not well described. METHODS Using the Outcomes Registry for Better Informed Treatment of AF, we analysed the incidence and predictors of progression and tested the discrimination(More)
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