Laila Arvola

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AIM Diadenosine polyphosphates are present intracellularly and in extracellular fluid due to release from secretory vesicles in platelets, chromaffin cells and other cells. This study investigates effects of diadenosine pentaphosphate (AP5A) on heart muscle function. METHODS Contractile force amplitude and action potential duration at 90% repolarization(More)
A sustained anti-beta-adrenergic effect of adenosine has been reported. This study was initiated to investigate this topic and especially elucidate the role of protein kinase C (PKC). Contractile force amplitude and action potential duration at 90% repolarization (APD90) were measured in guinea-pig papillary muscles before and after 5 min challenge with 5(More)
Angiopathy Presenting as an Expansive Process with Inflammation and Contrast Enhancement Cerebral amyloid angiopathy (CAA) is an important cause of cerebrovascular diseases because it can be treated. CAA may present as a cerebral tumor, but knowledge about the pathophysiology and clinical outcome in such cases is limited. A patient who developed rapid(More)
OBJECTIVE Anti-ss-adrenergic actions of several substances influence heart function significantly. The anti-ss-adrenergic effect of melatonin was investigated, with special attention to protein kinase C (PKC) and nitric oxide (NO). DESIGN Guinea pig papillary muscles were exposed to melatonin (500 pM) for 15 min and 20 min washout. Contractile force was(More)
OBJECTIVES Adenosine attenuates the effect of beta-adrenergic stimulation upon contractile force, both when present during beta-adrenergic stimulation and for a period after washout of adenosine. Protein kinase C (PKC) mediates the sustained effect. The present study investigated if bradykinin (500 nM) could induce anti-beta-adrenergic actions. DESIGN(More)
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