Lai Ming Fung

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In Caucasians, maturity-onset diabetes of the young (MODY) is mostly caused by mutations in the hepatocyte nuclear factor (HNF)-1α (MODY3) and glucokinase (MODY2) genes. Most Japanese MODY patients, however, are not linked to known MODY genes. In this study, we examined the genetic and clinical characteristics of Chinese subjects with MODY. The study(More)
OBJECTIVE We conducted a cohort study to determine the incidence and progression of diabetic retinopathy (DR) in a Chinese population with type 2 diabetes mellitus in a district hospital in Hong Kong, and to identify the risk factors associated with the development and progression of DR over 4 years. RESEARCH DESIGN AND METHODS A total of 413 type 2(More)
Phaeochromocytoma or paraganglioma that exclusively secretes dopamine is very rare. This case illustrates its atypical presentation and the importance of interpretative reporting for urine catecholamines leading to the diagnosis and subsequent management of a patient with this condition. We report a 71-year-old Chinese woman with a large dopamine-secreting(More)
Pseudohypoparathyroidism is a rare genetic disorder characterised by end-organ resistance to parathyroid hormone due to a defect of the guanine nucleotide-binding protein alpha that simulates activity of the polypeptide 1 (GNAS) gene. Patients with type 1a pseudohypoparathyroidism display different features of Albright's hereditary osteodystrophy as well as(More)
Key Messages 1. Type 2 diabetic patients with chronic kidney disease receiving structured care (SC) by a diabetologist-nurse team or usual care (UC) had a similar incidence of end-stage renal disease (24 of 104 vs 24 of 101) after intervention for 2 years. 2. Patients receiving SC were three times more likely to attain three or more predefined treatment(More)
There is limited information on the accuracy of bioelectrical impedance analysis (BIA) for estimating body composition in children. The purpose of this study was to evaluate BIA measurements for estimating fat mass and fat-free mass in 94 Chinese boys and girls aged 11-17 years. Percent fat (%fatskf) and fat-free mass (FFMskf) were predicted by regression(More)
Mutations in the SLC22A5 gene, which encodes for the plasma membrane carnitine transporter OCTN2, cause primary carnitine deficiency (PCD). After our first report of OCTN2 mutations in Chinese, three more Chinese PCD patients were identified. The parents of these families were non-consanguineous and these families were unrelated. Two novel truncating(More)
OBJECTIVE To review the clinical manifestations of phaeochromocytoma in a Hong Kong Chinese population. DESIGN Retrospective review. SETTING. Five public hospitals in Hong Kong. PATIENTS Seventeen patients with operated phaeochromocytoma between 1994 and 2003 were reviewed retrospectively. RESULTS Six patients (35%) were men, 11 (65%) were women. The(More)
Blood flow across the atrioventricular valves and outflow tracts was measured in 55 normal fetuses and 32 fetuses with haemoglobin (Hb) Bart's disease between 18 and 26 weeks of gestation. The mean velocities remained unchanged in both normal and affected fetuses over the gestations studied. The volume flow across both atrioventricular valves and outflow(More)
Congestive heart failure is a recognised complication of uncontrolled thyrotoxicosis but isolated right heart failure is rarely seen in association with thyrotoxicosis. Two cases of right heart failure associated with thyrotoxicosis are presented. In a 45-year-old man with right heart failure, investigations for all common secondary causes of right heart(More)