Ladislav Dusek

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The Internet-based system DIOS addresses the issues of anti-tumor chemotherapy and its evaluation. The repository of chemotherapeutic regimens (CHRs) stored in XML structured format constitutes the core of the system. Several applications have been created based on this repository, in order to allow users to browse current CHRs and procedures of planning(More)
INTRODUCTION The prognosis of patients hospitalized with acute heart failure (AHF) is poor and risk stratification may help clinicians guide care. The objectives of the Acute Heart Failure Database (AHEAD) registry are to assess patient characteristics, etiology, treatment and outcome of AHF. METHODS The AHEAD main registry includes patients hospitalized(More)
OBJECTIVE To evaluate the effects of ropinirole on selected nonmotor symptoms of Parkinson's disease (PD), including anxiety, depressive symptoms, sleep disturbances/excessive daytime sleepiness, and sexual functions. METHODS Forty-four consecutive PD patients with or without motor complications (MC+ group and MC- group, respectively); 6-month prospective(More)
  • Lubomir Slavicek, Tomas Pavlik, Jiri Tomasek, Zbynek Bortlicek, Tomas Buchler, Bohuslav Melichar +5 others
  • 2014
BACKGROUND Patients aged 65 years and older represent the majority of patients with metastatic colorectal cancer (mCRC). However, this patient population is often underrepresented in clinical trials and probably undertreated in the clinical practice. METHODS We have analysed the outcomes of 3,187 mCRC patients treated with first-line bevacizumab based on(More)
The synthesis of existing Persistent Organic Pollutants pollution monitoring databases with epidemiological data is considered for identifying some impacts of Persistent Organic Pollutants on human health. This task requires new rich data, services, and model discovery capabilities from a multitude of monitoring networks and web resources. The FP7 project(More)
Depression is frequently comorbid with a drug addiction and may seriously complicate its treatment. Currently, there is no routinely used animal model to investigate this comorbidity. In this study the effect of repeated administration of methamphetamine on i.v. drug self-administration in an olfactory bulbectomy model of depression in rats was investigated(More)
  • Beatrix Bencsikova, Zbynek Bortlicek, Jana Halamkova, Lenka Ostrizkova, Igor Kiss, Bohuslav Melichar +5 others
  • 2015
BACKGROUND The aim of the present retrospective study was to analyze clinical outcome and risk factors associated with treatment outcomes according to KRAS status in patient with metastatic colorectal cancer (mCRC) treated with bevacizumab (bev) plus chemotherapy in the first-line setting. METHODS We performed observational study on 1622 patients with(More)
  • Pavel Jansa, Jiri Jarkovsky, Hikmet Al-Hiti, Jana Popelova, David Ambroz, Tomas Zatocil +7 others
  • 2014
BACKGROUND Pulmonary arterial hypertension (PAH) is a severe and progressive disease characterized by increased pulmonary vascular resistance, ultimately leading to right heart failure and death. Epidemiological data from national registries are growing worldwide, but are still unavailable in Eastern Europe. METHODS A PAH registry was initiated in January(More)
  • Petra Amchova, Jana Kucerova, Valentina Giugliano, Zuzana Babinska, Mary T. Zanda, Maria Scherma +6 others
  • 2014
Depression has been associated with drug consumption, including heavy or problematic cannabis use. According to an animal model of depression and substance use disorder comorbidity, we combined the olfactory bulbectomy (OBX) model of depression with intravenous drug self-administration procedure to verify whether depressive-like rats displayed altered(More)
Patients with lung cancer experience elevated risk of venous thromboembolism. Cancer patients with thrombosis have a shorter life expectancy and the occurrence of VTE worsens the quality of life and may delay, interrupt, or completely halt the cancer therapy. In a large cohort of lung cancer patients we monitored the incidence of venous thromboembolism and(More)