Lachlan Brumley

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UDP-glucose:glycoprotein glucose-1-phosphotransferase (Glc-phosphotransferase) catalyzes the transfer of Glc-1-P from UDP-Glc to mannose residues on acceptor glycoproteins. The predominant acceptor in vertebrates and Paramecium tetraurelia is a cytoplasmic 62-kDa glycoprotein. To determine if the yeast Saccharomyces cerevisiae also possesses(More)
A calmodulin-dependent protein phosphatase (calcineurin) was converted to an active, calmodulin-independent form by a Ca2+-dependent protease (calpain I). Proteolysis could be blocked by ethylene glycol bis(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid, leupeptin, or N-ethylmaleimide, but other protease inhibitors such as phenylmethanesulfonyl fluoride,(More)
The calmodulin and C-kinase antagonists melittin, calmidazolium, N-(6-aminohexyl)-5-chloro-1-napthalenesulfonamide (W7), and trifluoperazine (TFP) also inhibit the activity of the human erythrocyte Ca2+-dependent protease, calpain I. W-5, the nonchlorinated derivative of W-7, was ineffective as an inhibitor of calpain I just as it is for calmodulin and(More)
Hormones and other extracellular proteins exert their effects on the cells that they influence by interacting with receptors in the plasma membranes of these target cells. For these interactions to occur, the receptor proteins must be efficiently synthesized, processed, and transported to the plasma membrane. This review summarizes the events and organelles(More)
This paper develops a theoretical model of the internal processes of the Orientation step of Boyd's OODA loop model. The Orientation step is important from an Information Warfare perspective as it is where the decision-maker combines their existing knowledge with new information. Any new information is a potential target for manipulation by Information(More)