Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study
- M. Herkenham, Abigail K. Lynn, M.Ross Johnson, LS Melvin, B. de Costa, K. Rice
- Biology, ChemistryJournal of Neuroscience
- 1 February 1991
The results suggest that the presently characterized cannabinoid receptor mediates physiological and behavioral effects of natural and synthetic cannabinoids, because it is strongly coupled to guanine nucleotide regulatory proteins and is discretely localized to cortical, basal ganglia, and cerebellar structures involved with cognition and movement.