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Fluorescence in situ hybridization (FISH) was used to construct a homology map to analyse the extent of evolutionary conservation of chromosome segments between human and rabbit (Oryctolagus cuniculus, 2n = 44). Chromosome-specific probes were established by bivariate fluorescence activated flow sorting followed by degenerate oligonucleotide-primed PCR(More)
Due to their aggressive nature, male mice are less frequently used than female mice in biomedical research. When aggressive males are being used, individual housing is common practice. The question arises whether this is an acceptable housing for a social species. The present study was designed to gain more insight into the nature of inter-male social(More)
Environmental enrichment may improve the quality of life of captive animals by altering the environment of animals so that they are able to perform more of the behavior that is within the range of the animal's species-specific repertoire. When enrichment is introduced into an animal's environment, it is important to evaluate the effect of the enrichment(More)
The HXB/Ipcv and BXH/Cub sets of recombinant inbred (RI) strains were derived from the spontaneously hypertensive rats (SHR/OlaIpcv) and normotensive Brown Norway (BN-Lx/Cub) rats. The RI strains were produced as a model system for genetic and correlation analysis of spontaneous hypertension and other risk factors of cardiovascular disease such as insulin(More)
The feeding of cholesterol-rich diets to random-bred animals results in marked interindividual differences in the response of serum cholesterol. Certain animals show only small responses (hyporesponders), whereas others develop high degrees of hypercholesterolemia (hyperresponders). Inbred strains of rabbits, rats, and mice differing in their sensitivity to(More)
Rabbit atropinesterase and cocainesterase were studied by starch gel electro-phoresis. The enzymes are localized in a region of the gels anodal to the albumins (prealbumin esterases). In this region, three groups of esterase zones (S, F, and D) can be distinguished. The S and F zones are almost exclusively responsible for the hydrolysis of cocaine and(More)
In order to obtain practical experience on the recognition, assessment and evaluation of discomfort in laboratory animals, the degree of discomfort was studied in gallstone-free and gallstone-bearing mice. Out of nine parameters to which scores were assigned per individual mouse, only the response to palpation of the right hypochondrium was found to score(More)
Behavioural and psychological needs of laboratory animals generally cannot adequately be met in standard laboratory cages. Environmental enrichment, which provides a more structured environment can enhance the well-being of laboratory animals. They may perform more of their species-specific behaviour and may control their environment in a better way. An(More)
Plasma lipoproteins, plasma activities of lecithin:cholesterol acyltransferase (LCAT), phospholipid transfer protein (PLTP), cholesteryl ester transfer protein (CETP) and post-heparin lipases were measured before and after cholesterol challenge in two inbred strains of rabbits with either a high (hyper-responders) or a low (hyporesponders) response of(More)
By searching the EMBL nucleotide database a total of 157 rabbit nuclear gene microsatellites were obtained (VAN LITH and VAN ZUTPHEN, Animal Genetics 27, 387-395, 1996). Thirteen of these were analysed by PCR to examine the degree of polymorphism of the amplified fragments in rabbits from different breeds. The 13 pairs of primers resulted in polymorphic(More)