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Sterilization has become the single most prevalent method of family planning on an international scale. It is estimated that approximately 80 million surgical sterilization procedures have been performed since the early 195Os, and the majority of these have been female.' The demand for female sterilization is growing, and there is a clear need for a safe(More)
To determine the safety of transcervical administration of quinacrine pellets as a method of voluntary female sterilization, three noncomparative Phase I clinical trials of the administration of 250 mg quinacrine were carried out in 21 women who were scheduled to undergo hysterectomy 24 h or one month later. Detailed results are presented for one of the(More)
The histologic changes that occur when quinacrine is placed into the uterus have not been well documented.' In addition, the sequential process involved remains unclear. In this chapter, we will briefly describe a sequence of histopathologic changes taking place in the cornual portion of the fallopian tube subsequent to exposure to quinacrine. This(More)
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