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The infant mouse has proved to be a useful model for examination of various aspects of gastrointestinal and systemic candidosis. Oral-intragastric inoculation of 5-6-day-old mice with yeast of a virulent strain of Candida albicans (CA30) resulted in systemic spread within 30 min after challenge. Histological examinations of the gastrointestinal (GI) tract(More)
In our earlier investigations it has been shown that the gastrointestinal (GI) tract of the infant mouse (4-5 days old) can be colonized following a single intragastric challenge with Candida albicans. This makes it possible to investigate the sequence of events which occur during colonization of the GI tract by this opportunistic yeast. Two strains of C.(More)
1. Myofibrillar protein degradation has been measured by the rate of 3-methylhistidine excretion in premature infants weighing between 635 g and 1295 g. Analyses were made in conjunction with 1--3 day nitrogen balance studies. 2. In 56 balance studies in 36 infants, total muscle protein breakdown varied between 0.70 and 2.58 (mean 1.05) g day-1 kg-1 body(More)
Infant mice have been shown previously to be a useful model for the study of gastrointestinal (GI) and systemic candidosis. In this study, the virulence of four strains of Candida albicans was compared in intragastrically inoculated infants and in adult mice inoculated intravenously. The four strains differed in their ability to kill both infant and adult(More)
Studies of host-parasite interactions involved in gastrointestinal and systemic candidosis have been hampered by the lack of suitable animal models which mimic the disease in humans. The infant mouse has proved to be a realistic and useful model for studies of candidosis. Oral-intragastric inoculation of infants leads to systemic spread and lethality(More)
Oral-intragastric inoculation of 6-day-old outbred Crl:CFW(SW) BR mice with Candida albicans can lead to colonization of the gastrointestinal (GI) tract. We have shown that in the absence of an immunocompromising treatment, Candida is primarily localized in the stomach and intestines of mice at 20 days post-inoculation. Cultures of homogenates of the(More)
Systemic and gastrointestinal infection can be established in infant mice after intragastric challenge with Candida albicans. Differences in virulence of the six strains tested were noted. As early as 3 h after infection, some but not all livers, spleens, and kidneys contained C. albicans, but the peak number of colony-forming units in these organs was seen(More)
Nitrobacter agilis, grown through seven transfers heterotrophically in the absence of nitrite, was examined in the electron microscope. The ultrastructure of such cells closely resembled that of autotrophically grown N. agilis. It was thus futher established that the organisms growing heterotrophically were indeed N. agilis and, therefore, that N. agilis is(More)