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The effects of variation in calcium concentration on the action potential of Purkinje fibers isolated from the dog heart were studied. Action potentials recorded during perfusion with Tyrode solution containing 2.7 mM calcium chloride were compared with those recorded during subsequent perfusion with solutions containing 0.675 (l / 4 x) , 1.35 (l / 2 x) ,(More)
The electrophysiologic properties of flecainide, a new potent antiarrhythmic drug, are poorly defined. In this study, they were investigated by standard microelectrode technique in isolated cardiac muscle from rabbit and dog hearts. The concentrations of flecainide used were between 0.1 and 10.0 micrograms/ml. Flecainide produced a concentration-dependent(More)
  • L D Davis
  • 1975
Isolated canine atrial plateau fibers were treated with acetylcholine or norepinephrine to note the effects on the transmembrane potential. Acetylcholine, 1.0 or 2.0 mug/ml, consistently reduced the slope of inherent phase 4 depolarization. Increases in maximum diastolic potential and rising velocity occurred along with a decrease in overshoot. The plateau(More)
We studied aspects of perinatal rat bronchiolar Clara cell development. We found that the volume density (Vv) of glycogen areas decreased 10-fold between postnatal days 1 and 2 and that the Vv of secretory granules, rough endoplasmic reticulum (RER), and mitochondria increased markedly during the 1st postnatal wk. Compared with pups of dams allowed food ad(More)
Right atria from excised beating dog hearts were immersed in Tyrode solution with the endocardial surface of the anterior wall exposed. Glass microelectrodes were used to impale fibers in different anatomical areas of this preparation. Fibers with action potentials similar in contour to those of ven-tricular Purkinje fibers were found along the caval border(More)
1. Young goats were used to study factors contributing to atherosclerosis. 2. Cholesterol in egg yolk affected plasma cholesterol concentration more than did a similar amount of crystalline cholesterol in the diet. 3. Goats fed high fat diets developed fatty lesions in their aortas. 4. Cholesterol concentration in low-density lipoprotein was greatest in(More)