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Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice Is Mediated via the IL-23/IL-17 Axis1
TLDR
The sole application of the innate TLR7/8 ligand IMQ rapidly induces a dermatitis closely resembling human psoriasis, critically dependent on the IL-23/IL-17 axis. Expand
ORCA3, a jasmonate-responsive transcriptional regulator of plant primary and secondary metabolism.
TLDR
Orca3 overexpression resulted in enhanced expression of several metabolite biosynthetic genes and in increased accumulation of terpenoid indole alkaloids, which may link plant stress responses to changes in metabolism. Expand
Zinc Finger Proteins Act as Transcriptional Repressors of Alkaloid Biosynthesis Genes in Catharanthus roseus*
TLDR
Results suggest that the ZCT proteins act as repressors in the regulation of elicitor-induced secondary metabolism in C. roseus. Expand
Effects of over-expression of strictosidine synthase and tryptophan decarboxylase on alkaloid production by cell cultures of Catharanthus roseus
TLDR
It is concluded that constitutive over-expression of Str is highly desirable for increased TIA production, however, given its complexity, limited intervention in the TIA pathway will yield positive results only in the presence of a favorable epigenetic environment. Expand
A site-specific recombinase is required for competitive root colonization by Pseudomonas fluorescens WCS365.
TLDR
The importance of phase variation in microbe-plant interactions is shown in terms of genetic rearrangements involved in the generation of different phenotypes, thereby allowing a bacterial population to occupy various habitats. Expand
The jasmonate-inducible AP2/ERF-domain transcription factor ORCA3 activates gene expression via interaction with a jasmonate-responsive promoter element.
TLDR
It is demonstrated that ORCA3 specifically binds to and activates gene expression via a previously characterized jasmonate- and elicitor-responsive element (JERE) in the promoter of the terpenoid indole alkaloid biosynthetic gene Strictosidine synthase (Str). Expand
The ternary transformation system: constitutive virG on a compatible plasmid dramatically increases Agrobacterium-mediated plant transformation
TLDR
It is demonstrated that Agrobacterium tumefaciens strain LBA4404 supplemented with a constitutive virG mutant gene (virGN54D) on a compatible plasmid is capable of very efficient T-DNA transfer to a diverse range of plant species. Expand
A Catharanthus roseus BPF-1 homologue interacts with an elicitor-responsive region of the secondary metabolite biosynthetic gene Str and is induced by elicitor via a JA-independent signal
TLDR
It is shown that an upstream region in the Str promoter confers responsiveness to partially purified yeast elicitor and jasmonate, and a novel binding site for BPF-1-like proteins with higher binding affinity than the previously described box P.P-binding factor-1. Expand
Evaluation of Immunophenotypic and Molecular Biomarkers for Sézary Syndrome Using Standard Operating Procedures: A Multicenter Study of 59 Patients.
TLDR
Peripheral blood CD4(+) T cells from 59 patients with Sézary syndrome and 19 patients with erythrodermic inflammatory dermatoses were analyzed for cell surface proteins by flow cytometry and for copy number alterations and differential gene expression using custom-made quantitative PCR plates. Expand
MicroRNA-21 expression in CD4+ T cells is regulated by STAT3 and is pathologically involved in Sézary syndrome.
TLDR
It is shown by chromatin immunoprecipitation that miR-21 is a direct STAT3 target in Sézary cells and might represent a therapeutic target for the treatment of SS. Expand
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