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The impact of culture isolation of Aspergillus species: a hospital-based survey of aspergillosis.
TLDR
The impact of a culture positive for Aspergillus species on the diagnosis, risk factors, management, and outcome associated with these diseases, including invasive aspergillosis, is examined in 24 medical centers. Expand
Immunopathogenesis of Oropharyngeal Candidiasis in Human Immunodeficiency Virus Infection
TLDR
A novel model of mucosal candidiasis is devised that closely mimics the clinical and pathological features of candidal infection in human HIV infection and allows, for the first time, a precise cause-and-effect analysis of the immunopathogenesis of mucosa candidiasis in HIV infection under controlled conditions in a small laboratory animal. Expand
Repeated-Dose Pharmacokinetics of an Oral Solution of Itraconazole in Infants and Children
TLDR
An itraconazole oral solution given at 5 mg/kg/day provides potentially therapeutic concentrations in plasma, which are substantially lower than those attained in adult cancer patients, and is well tolerated and safe in infants and children. Expand
Comparison of enzyme immunoassay and gas-liquid chromatography for the rapid diagnosis of invasive candidiasis in cancer patients
TLDR
The best approach to diagnosing invasive candidiasis involves obtaining blood cultures and carrying out serial assays for mannan in serum, which combines the sensitivity and specificity of arabinitol, mannose, andcreatinine. Expand
Evidence for differential expression of candida albicans virulence genes during oral infection in intact and human immunodeficiency virus type 1-transgenic mice.
TLDR
Findings indicate that expression of individual members of the C. albicans SAP gene family is differentially regulated during experimental OPC. Expand
Serodiagnosis of candidiasis, aspergillosis, and cryptococcosis.
TLDR
The usefulness of detection of antigenemia in invasive candidiasis and invasive aspergillosis has been limited by the rapid clearance of Candida mannan and Aspergillus galactomannan from serum, which results in only moderate sensitivity for disease. Expand
Current trends in immunodiagnosis of candidiasis and aspergillosis.
TLDR
The methods and reagents currently used for the immunodiagnosis of aspergillosis and candidiasis are reviewed and studies are being carried out to increase the sensitivity and reliability of these tests through the use of monoclonal antibodies and purified, clinically relevant antigens. Expand
Detection of galactomannan antigenemia by enzyme immunoassay in experimental invasive aspergillosis
TLDR
A sensitive enzyme immunoassay for galactomannan antigenemia that avoids the use of radioisotopes was devised and the best immunoglobulin G response (1/8,000) was obtained against CA in rabbits immunized intravenously with cell walls. Expand
Characteristics and outcome of infants with candiduria in neonatal intensive care - a Paediatric Investigators Collaborative Network on Infections in Canada (PICNIC) study
TLDR
The overall mortality rate in these infants was significant, and Candida infection was deemed to be a contributing factor, suggesting the need for antifungal therapy with repeat evaluation for dissemination in infants who are slow to respond to therapy. Expand
Acquired immunity in experimental murine aspergillosis is mediated by macrophages
TLDR
Results indicate that acquired immunity mediated by activated macrophages can be demonstrated in experimental murine aspergillosis in mice inoculated with Aspergillus fumigatus conidia. Expand
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