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Inhibition of growth of colon 38 adenocarcinoma by vinblastine and colchicine: evidence for a vascular mechanism.
TLDR
The results suggest that vinca alkaloids and colchicine act on solid tumours by host cell-mediated vascular effects as well as by direct tubulin-mediated cytotoxicity. Expand
Tumor-dependent increased plasma nitrate concentrations as an indication of the antitumor effect of flavone-8-acetic acid and analogues in mice.
TLDR
It is shown here that FAA and structurally related analogues increase plasma nitrite plus nitrate (NO2-/NO3-) levels in mice, suggesting that nitric oxide may contribute to tumor cell death by two mechanisms, alteration of blood flow contributing to tumor ischemia and direct tumor cell killing. Expand
Serotonin involvement in the antitumour and host effects of flavone-8-acetic acid and 5,6-dimethylxanthenone-4-acetic acid
TLDR
It is suggested that serotonin is necessary for the induction of nitric oxide synthases and acts, either directly or indirectly, in concert with TNF. Expand
Comparative Pharmacokinetics of Baicalin, Wogonoside, Baicalein and Wogonin in Plasma after Oral Administration of Pure Baicalin, Radix Scutellariae and Scutellariae-Paeoniae Couple Extracts in
TLDR
The results showed that wogonoside, possibily as a methylated product of baicalin, was found in plasma after oral administration of pure baicalsin or formulas to rats, and ulcerative colitis rats showed better absorption than normal rats. Expand
Role of lipophilicity in determining cellular uptake and antitumour activity of gold phosphine complexes
TLDR
Alteration of lipophilicity of aromatic cationic antitumour drugs greatly affects cellular uptake and binding to plasma proteins, and optimal lipophILicity may be a critical factor in the design of analogues with high antitumours activity. Expand
Increased plasma serotonin following treatment with flavone-8-acetic acid, 5,6-dimethylxanthenone-4-acetic acid, vinblastine, and colchicine: relation to vascular effects.
TLDR
It is suggested that the increases in plasma serotonin and its metabolite are a result of drug-induced vascular effects in host tissues, and that measurement of these compounds provides a potential means of monitoring drugs exerting vascular effects. Expand
Experimental solid tumour activity ofN-[2-(dimethylamino)ethyl]-acridine-4-carboxamide
TLDR
The activity of DACA was comparable with that of 5-fluorouracil and superior to that of doxorubicin, cyclophosphamide and the experimental amsacrine analogue CI-921, which demonstrated significant activity against the NZM3 melanoma human cell line growing as a xenograft in athymic mice. Expand
Synthesis and cytotoxic activity of carboxamide derivatives of benzo[b][1,6]naphthyridines.
TLDR
Five derived 4-N-[2-(dimethylamino)ethyl]carboxamides were tested for growth inhibitory properties against murine P388 leukemia, Lewis lung carcinoma (LLTC), and human Jurkat leukemia cell lines, and most compounds were potent cytotoxins, with some having IC(50) values less than 10 nM. Expand
Effects of the serotonin receptor antagonist cyproheptadine on the activity and pharmacokinetics of 5,6-dimethylxanthenone-4-acetic acid (DMXAA)
TLDR
The augmentation by cyproheptadine of the induction of tumour response to DMXAA reflects a pharmacological interaction, leading to increased plasma and tumour half-lives, and to reduced excretion. Expand
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