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IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
T helper cells that produce interleukin 17 (IL-17; 'TH-17 cells') are a distinct subset of proinflammatory cells whose in vivo function requires IL-23 but whose in vitro differentiation requires only… Expand
Plasticity of CD4+ T cell lineage differentiation.
The differentiation of naive CD4(+) T cells into lineages with distinct effector functions has been considered to be an irreversible event. T helper type 1 (Th1) cells stably express IFN-gamma,… Expand
The aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells.
Innate lymphoid cells (ILCs) expressing the nuclear receptor RORγt are essential for gut immunity presumably through production of interleukin-22 (IL-22). The molecular mechanism underlying the… Expand
176 IL-6 Programs TH-17 Cell Differentiation by Promoting the Sequential Engagement of the IL-21 and IL-23 Pathways
Commensal bacteria protect against food allergen sensitization
- A. Stefka, Taylor Feehley, +12 authors C. Nagler
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 25 August 2014
Significance The prevalence of food allergy is rising at an alarming rate; the US Centers for Disease Control and Prevention documented an 18% increase among children in the United States between… Expand
Integrated Profiling of MicroRNAs and mRNAs: MicroRNAs Located on Xq27.3 Associate with Clear Cell Renal Cell Carcinoma
Background With the advent of second-generation sequencing, the expression of gene transcripts can be digitally measured with high accuracy. The purpose of this study was to systematically profile… Expand
Transcriptional regulation of Th17 cell differentiation.
The paradigm of effector T helper cell differentiation into either Th1 or Th2 lineages has been profoundly shaken by the discovery of T cells that secrete IL-17 and other inflammatory cytokines. This… Expand
Genome‐wide survey by ChIP‐seq reveals YY1 regulation of lincRNAs in skeletal myogenesis
Skeletal muscle differentiation is orchestrated by a network of transcription factors, epigenetic regulators, and non‐coding RNAs. The transcription factor Yin Yang 1 (YY1) silences multiple target… Expand
Transcriptional regulatory networks in Th17 cell differentiation.
Upon encountering antigen in the context of antigen presenting cells, naïve CD4(+) T cells undergo differentiation into effector T helper (Th) cells, which can secrete high levels of cytokines and… Expand
MicroRNA-34a Targets Bcl-2 and Sensitizes Human Hepatocellular Carcinoma Cells to Sorafenib Treatment
- F. Yang, Q. Li, +9 authors K. Dou
- Biology, Medicine
- Technology in cancer research & treatment
- 1 February 2014
MiR-34a, a direct target of p53, has been shown to target several molecules associated with the cell cycle and cell survival pathways, and its dysregulation is implicated in cancer drug resistance or… Expand