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Genetic Structure of Human Populations
- N. Rosenberg, J. Pritchard, M. Feldman
- BiologyScience
- 20 December 2002
General agreement of genetic and predefined populations suggests that self-reported ancestry can facilitate assessments of epidemiological risks but does not obviate the need to use genetic information in genetic association studies.
Estimating population structure in diploids with multilocus dominant DNA markers
- L. Zhivotovsky
- BiologyMolecular Ecology
- 1 June 1999
A Bayesian approach to estimation of null‐allele frequencies for dominant DNA markers is introduced and it is shown that the Bayesian method gives nearly unbiased estimates of heterozygosity, genetic distances and F‐statistics.
Truncated product method for combining P‐values
- D. Zaykin, L. Zhivotovsky, P. Westfall, B. Weir
- MathematicsGenetic Epidemiology
- 1 February 2002
A new procedure to take the product of only those P‐values less than some specified cut‐off value and to evaluate the probability of such a product, or a smaller value, under the overall hypothesis that all L hypotheses are true is presented.
The effective mutation rate at Y chromosome short tandem repeats, with application to human population-divergence time.
- L. Zhivotovsky, P. Underhill, L. Kalaydjieva
- BiologyAmerican Journal of Human Genetics
- 2004
This value is used to estimate the times of the African Bantu expansion, the divergence of Polynesian populations (the Maoris, Cook Islanders, and Samoans), and the origin of Gypsy populations from Bulgaria.
Polarity and temporality of high-resolution y-chromosome distributions in India identify both indigenous and exogenous expansions and reveal minor genetic influence of Central Asian pastoralists.
- S. Sengupta, L. Zhivotovsky, P. Underhill
- BiologyAmerican Journal of Human Genetics
- 1 February 2006
The reappraisal indicates that pre-Holocene and Holocene-era--not Indo-European--expansions have shaped the distinctive South Asian Y-chromosome landscape.
Origin, diffusion, and differentiation of Y-chromosome haplogroups E and J: inferences on the neolithization of Europe and later migratory events in the Mediterranean area.
- O. Semino, C. Magri, A. Santachiara‐Benerecetti
- BiologyAmerican Journal of Human Genetics
- 1 May 2004
The phylogeography of Y-chromosome haplogroups E and J was investigated in >2400 subjects from 29 populations, mainly from Europe and the Mediterranean area but also from Africa and Asia, revealing spatial patterns that are consistent with a Levantine/Anatolian dispersal route to southeastern Europe.
High-resolution SNPs and microsatellite haplotypes point to a single, recent entry of Native American Y chromosomes into the Americas.
- S. Zegura, T. Karafet, L. Zhivotovsky, M. Hammer
- BiologyMolecular biology and evolution
- 31 October 2003
The hypothesis of a single migration of a polymorphic founding population better fits the expanded database and traced both lineages to a probable ancestral homeland in the vicinity of the Altai Mountains in Southwest Siberia.
Features of evolution and expansion of modern humans, inferred from genomewide microsatellite markers.
- L. Zhivotovsky, N. Rosenberg, M. Feldman
- BiologyAmerican Journal of Human Genetics
- 1 May 2003
Variation at di-, tri-, and tetranucleotide repeat loci is distributed differently, although each class of markers exhibits a decrease of within-population genetic variation in the following order: sub-Saharan Africa, Eurasia, East Asia, Oceania, and America.
Phylogeography of Y-chromosome haplogroup I reveals distinct domains of prehistoric gene flow in europe.
Haplogroup I, the only major clade of the Y phylogeny that is widespread over Europe but virtually absent elsewhere, is analyzed, in detail, and it is revealed that it underwent a postglacial expansion and marked the human colonization of Sardinia approximately 9,000 years ago.
Melanesian and Asian origins of Polynesians: mtDNA and Y chromosome gradients across the Pacific.
- M. Kayser, S. Brauer, M. Stoneking
- BiologyMolecular biology and evolution
- 1 November 2006
Surprisingly, gradients in the frequency distribution of some NRY/mtDNA haplogroups across Polynesia and a gradual west-to-east decrease of overall Nry/mt DNA diversity are identified, providing evidence for a west- to-east direction of Polynesian settlements but also suggesting that Pacific voyaging was regular rather than haphazard.
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