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Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients
Good bacteria help fight cancer Resident gut bacteria can affect patient responses to cancer immunotherapy (see the Perspective by Jobin). Routy et al. show that antibiotic consumption is associatedExpand
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Origin and Spread of de Novo Genes in Drosophila melanogaster Populations
Novel genes derived from ancestral noncoding sequences are polymorphic among fruit fly strains. Comparative genomic analyses have revealed that genes may arise from ancestrally nongenic sequence.Expand
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Seismic tomography of Taiwan: Improved constraints from a dense network of strong motion stations
In this study, a large collection of 41,141 S-P times from the untapped records of the Taiwan Strong Motion Instrumentation Program (TSMIP) network is combined with the P and S wave arrival timesExpand
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The genome of the hydatid tapeworm Echinococcus granulosus
Cystic echinococcosis (hydatid disease), caused by the tapeworm E. granulosus, is responsible for considerable human morbidity and mortality. This cosmopolitan disease is difficult to diagnose, treatExpand
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miR172 regulates stem cell fate and defines the inner boundary of APETALA3 and PISTILLATA expression domain in Arabidopsis floral meristems.
In Arabidopsis, two floral homeotic genes APETALA2 (AP2) and AGAMOUS (AG) specify the identities of perianth and reproductive organs, respectively, in flower development. The two genes actExpand
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Interleukin-17 Contributes to the Pathogenesis of Autoimmune Hepatitis through Inducing Hepatic Interleukin-6 Expression
T helper cells that produce IL-17 (Th17 cells) have recently been identified as the third distinct subset of effector T cells. Emerging data suggests that Th17 cells play an important role in theExpand
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The Islet β Cell-enriched MafA Activator Is a Key Regulator of Insulin Gene Transcription*
The islet-enriched MafA, PDX-1, and BETA2 activators contribute to both β cell-specific and glucose-responsive insulin gene transcription. To investigate how these factors impart activation, theirExpand
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Members of the Large Maf Transcription Family Regulate Insulin Gene Transcription in Islet β Cells
ABSTRACT The C1/RIPE3b1 (−118/−107 bp) binding factor regulates pancreatic-β-cell-specific and glucose-regulated transcription of the insulin gene. In the present study, the C1/RIPE3b1 activator fromExpand
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PRMT7 induces epithelial-to-mesenchymal transition and promotes metastasis in breast cancer.
Epithelial-to-mesenchymal transition (EMT) enables metastasis. E-cadherin loss is a hallmark of EMT, but there remains an incomplete understanding of the epigenetics of this process. The proteinExpand
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Disruption of SoxB1-dependent Sonic hedgehog expression in the hypothalamus causes septo-optic dysplasia.
Septo-optic dysplasia (SOD) is a congenital brain anomaly that results in pituitary, optic nerve, and midline forebrain defects. The etiology of SOD is poorly understood, with the majority of casesExpand
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