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The ORCA2 transcription factor plays a key role in regulation of the terpenoid indole alkaloid pathway
BackgroundThe terpenoid indole alkaloid (TIA) pathway leads to the production of pharmaceutically important drugs, such as the anticancer compounds vinblastine and vincristine. Unfortunately, theseExpand
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Functional Determinants of Human Enteric α-Defensin HD5
Background: Human α-defensin HD5 is a multifunctional antimicrobial peptide whose functional determinants have yet to be elucidated. Results: Alanine scanning mutagenesis aided by x-rayExpand
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CrBPF1 overexpression alters transcript levels of terpenoid indole alkaloid biosynthetic and regulatory genes
Terpenoid indole alkaloid (TIA) biosynthesis in Catharanthus roseus is a complex and highly regulated process. Understanding the biochemistry and regulation of the TIA pathway is of particularExpand
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Perspectives of the metabolic engineering of terpenoid indole alkaloids in Catharanthus roseus hairy roots.
This review looks back on how the terpenoid indole alkaloid pathway and the regulatory factors in Catharanthus roseus were identified and characterized, and how metabolic engineering, includingExpand
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Metabolic engineering with plants for a sustainable biobased economy.
Plants are bona fide sustainable organisms because they accumulate carbon and synthesize beneficial metabolites from photosynthesis. To meet the challenges to food security and health threatened byExpand
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Changes of chemical composition and source apportionment of PM2.5 during 2013–2017 in urban Handan, China
Abstract China implemented the National Air Pollution Prevention and Control Action Plan since 2013, aiming at significantly improving air quality in major areas and cities in 2017. To investigateExpand
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Two distinct domains contribute to the substrate acyl chain length selectivity of plant acyl-ACP thioesterase
The substrate specificity of acyl-ACP thioesterase (TE) plays an essential role in controlling the fatty acid profile produced by type II fatty acid synthases. Here we identify two groups of residuesExpand
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Evolution of Key Chemical Components in PM2.5 and Potential Formation Mechanisms of Serious Haze Events in Handan, China
Handan has been one of the most polluted cities in China since 2013 and became the top city for PM2.5 in 2017. In this research, we observed coarse particulate matter (PM10), fine particulate matterExpand
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Epigenetic Targets and their Inhibitors in Cancer Therapy.
Epigenetics is defined as the stable and heritable alternations in gene expression without changing the DNA nucleotide sequence. The initiation and progression of cancer result from not only geneticExpand
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dbCPM: a manually curated database for exploring the cancer passenger mutations
We developed a comprehensive literature-based database of Cancer Passenger Mutations (dbCPM), which contains 941 experimentally supported and 978 putative passenger mutations derived from a manual curation of the literature. Expand
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