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Use of allelic loss to predict malignant risk for low-grade oral epithelial dysplasia.
  • M. Rosin, X. Cheng, +8 authors L. Zhang
  • Medicine, Biology
  • Clinical cancer research : an official journal of…
  • 1 February 2000
TLDR
Analysis of LOH at 3p and 9p could serve as an initial screening for cancer risk of early premalignancies and follow-up investigation for additional losses would be essential for predicting cancer progression. Expand
Heightened endoplasmic reticulum stress in the lungs of patients with chronic obstructive pulmonary disease: the role of Nrf2-regulated proteasomal activity.
TLDR
Impaired Nrf2 signaling causes significant decline in proteasomal activity and heightens ER stress response in lungs of patients with COPD and CS-exposed mice, and pharmacological approaches that augment NRF2 activity may protect against COPD progression by both up-regulating antioxidant defenses and relieving ER stress. Expand
Toll-like receptor 7 and 9 defects in common variable immunodeficiency.
TLDR
Defective TLR7 and TLR9 signaling in CVID B cells and pDCs, coupled with deficient IFN-alpha, impairs CVIDB cell functions and prevents TLR-mediated augmentation of humoral immunity in vivo. Expand
Volumetric brain changes in females with fragile X-associated tremor/ataxia syndrome (FXTAS)
TLDR
Females affected by fragile X-associated tremor/ataxia syndrome (FXTAS) demonstrated milder brain changes than affected males, although they showed a similar pattern of radiologic findings consistent with brain atrophy and white matter disease. Expand
Initial diagnoses given to persons with the fragile X associated tremor/ataxia syndrome (FXTAS)
TLDR
Patients with FXTAS were given 98 prior diagnoses: most were in the categories of parkinsonism, tremor, ataxia, dementia, or stroke, and data from this study and others were used to develop guidelines for FMR1 diagnostic testing forFXTAS. Expand
Lysosomal membranes from beige mice contain higher than normal levels of endoplasmic reticulum proteins.
TLDR
The results suggest that LYST may play a role in either preventing inappropriate incorporation of proteins into the lysosomal membrane or in membrane recycling/maturation. Expand
Long Noncoding RNAs in Atherosclerosis.
TLDR
This study summarized and highlighted the lncRNAs that play a role in the process of atherosclerosis and may provide helpful insights regarding further study of lnc RNAs associated with atheros sclerosis. Expand
TLR-Mediated B Cell Defects and IFN-α in Common Variable Immunodeficiency
TLDR
TLR7 or TLR9 stimulation in the presence of IFN-α normalized isotype-switched CD27+ B cells, enhanced activation-induced cytidine deaminase mRNA, and significantly improved IgG production only for group 2 subjects, indicating that the loss of IFn-α could be a significant component of the B-cell defect for these subjects. Expand
In vitro expression levels of cell-cycle checkpoint proteins are associated with cellular DNA repair capacity in peripheral blood lymphocytes: a multivariate analysis.
TLDR
The results provide population-based in vitro evidence demonstrating that cell-cycle checkpoint-related proteins play essential roles in regulating DNA repair, at least in unaffected human peripheral blood lymphocytes. Expand
Risk Prediction of Cervical Cancer and Precancers by Type-Specific Human Papillomavirus: Evidence from a Population-Based Cohort Study in China
TLDR
The results support the risk-based management of HPV-positive women using HPV genotyping and also indicate the significance of including HPV 31 and 58 apart from commonly acknowledged HPV 16 and HPV 18 in achieving better risk stratification. Expand
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