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The microRNA miR-181c controls microglia-mediated neuronal apoptosis by suppressing tumor necrosis factor
- L. Zhang, Lian-Yan Dong, Ya-jian Li, Z. Hong, Wen-shi Wei
- Biology, Medicine
- Journal of Neuroinflammation
- 6 September 2012
BackgroundPost-ischemic microglial activation may contribute to neuronal damage through the release of large amounts of pro-inflammatory cytokines and neurotoxic factors. The involvement of microRNAs… Expand
MicroRNA‐181c negatively regulates the inflammatory response in oxygen‐glucose‐deprived microglia by targeting Toll‐like receptor 4
- L. Zhang, Ya-jian Li, Xun-yi Wu, Z. Hong, Wen-shi Wei
- Chemistry, Medicine
- Journal of neurochemistry
- 1 March 2015
Cerebral hypoxia/ischemia rapidly induces inflammation in the brain, which is characterized by microglial activation and the release of inflammatory cytokines. We have previously demonstrated that… Expand
Human chromosome 21 orthologous region on mouse chromosome 17 is a major determinant of Down syndrome-related developmental cognitive deficits.
Trisomy 21 (Down syndrome, DS) is the most common genetic cause of developmental cognitive deficits, and the so-called Down syndrome critical region (DSCR) has been proposed as a major determinant of… Expand
The expression of claudin 1 correlates with β-catenin and is a prognostic factor of poor outcome in gastric cancer.
- J. Huang, J. Li, +5 authors Zhenggang Zhu
- Biology, Medicine
- International journal of oncology
- 1 April 2014
Claudin 1 is one of the tight junction proteins, which are critical in the maintenance of epithelial integrity. Aberrant regulation of CLDN1 and its correlation with β-catenin have been discovered in… Expand
miR‐21 represses FasL in microglia and protects against microglia‐mediated neuronal cell death following hypoxia/ischemia
A growing body of evidence suggests that microRNA (miRNA) dysregulation contributes to many types of human disease, including central nervous system disorders. In this study, we identified an inverse… Expand
Recent insights into farnesoid X receptor in non-alcoholic fatty liver disease.
Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome and is one of the most prevalent liver disorders worldwide. NAFLD can gradually progress to liver… Expand
Oncogenic role of the chromobox protein CBX7 in gastric cancer
- X. Zhang, L. Zhang, +5 authors W. Guo
- Biology, Medicine
- Journal of experimental & clinical cancer…
- 19 August 2010
BackgroundChromobox 7 (CBX7) is a Polycomb family protein that extends the lifespan of normal human cells via downregulating the expression of INK4a/ARF tumor suppressor locus. It was found that CBX7… Expand
The effects of exercise preconditioning on cerebral blood flow change and endothelin-1 expression after cerebral ischemia in rats.
- Q. Zhang, L. Zhang, Xiaojiao Yang, Yonggan Wan, J. Jia
- Journal of stroke and cerebrovascular diseases…
- 1 July 2014
Stroke is an acute cerebrovascular disease with high incidence, morbidity, and mortality. Preischemic treadmill training has been shown to be effective in improving behavioral and neuropathologic… Expand
Parthenolide attenuates cerebral ischemia/reperfusion injury via Akt/GSK-3β pathway in PC12 cells.
- J. Zhang, L. Zhang, +8 authors Yingfang Tian
- Biomedicine & pharmacotherapy = Biomedecine…
- 1 May 2017
Parthenolide (PN), a sesquiterpene lactone isolated from the herbal medicine feverfew (Tanacetum parthenium), was reported to possess neuroprotective activity. However, the neuroprotective effect of… Expand
MicroRNA-378 suppresses myocardial fibrosis through a paracrine mechanism at the early stage of cardiac hypertrophy following mechanical stress.
Rationale: Excessive myocardial fibrosis is the main pathological process in the development of cardiac remodeling and heart failure; therefore, it is important to prevent excessive myocardial… Expand