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Membrane transporters in drug development
- K. Giacomini, Shiew-Mei Huang, +21 authors L. Zhang
- Nature Reviews Drug Discovery
- 1 March 2010
Overall, it is advised that the timing of transporter investigations should be driven by efficacy, safety and clinical trial enrolment questions, as well as a need for further understanding of the absorption, distribution, metabolism and excretion properties of the drug molecule, and information required for drug labelling. Expand
Zircon U–Pb ages and tectonic implications of Paleozoic plutons in northern West Junggar, North Xinjiang, China
Abstract North Xinjiang, Northwest China, is made up of several Paleozoic orogens. From north to south these are the Chinese Altai, Junggar, and Tian Shan. It is characterized by widespread… Expand
Positions of the East Asian cratons in the Neoproterozoic supercontinent Rodinia
Three major East Asian crustal blocks, the Tarim, North China and South China Blocks, have records of the Neoproterozoic rifting events that broke up the supercontinent Rodinia. A preliminary… Expand
Age, geochemistry, and tectonic implications of a late Paleozoic stitching pluton in the North Tian Shan suture zone, western China
The Central Asian orogenic belt is the largest tectonic assembly of continental and oceanic terranes on Earth due to closure of the paleo–Asian Ocean in the Phanerozoic. Among major suture zones in… Expand
Dietary exposure to persistent organochlorine pesticides in 2007 Chinese total diet study.
- P. Zhou, Yunfeng Zhao, +7 authors Yongning Wu
- Chemistry, Medicine
- Environment international
- 1 July 2012
The average and high end estimated daily intakes of different OCPs for the Chinese were both lower than the tolerable daily intake (TDI) suggested by authorities indicating low health risk of OCPS dietary exposure among Chinese adults at present, however, the risk of carcinogenicity of the O CPs should be concerned with. Expand
Dietary cadmium exposure assessment among the Chinese population
The findings indicated that the health risk from dietary cadmium exposure of the general Chinese people was low, but the healthrisk of cadmiam exposure of certain sub-groups should be of concern. Expand
Concentration of di(2-ethylhexyl) phthalate (DEHP) in foods and its dietary exposure in China.
- Hai-xia Sui, L. Zhang, +5 authors Zhaoping Liu
- International journal of hygiene and…
- 1 July 2014
Dietary exposure to DEHP among Chinese population was lower than tolerable daily intake of DEHP and there are no health concerns based on generally accepted exposure limits. Expand
A national survey of polychlorinated dioxins, furans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (dl-PCBs) in human milk in China.
In the study, both the TEQ body burden of the sample population and estimated daily TEQ intake of breast-feeding infants were lower than those of developed countries. Expand
Polybrominated diphenyl ethers (PBDEs) and indicator polychlorinated biphenyls (PCBs) in foods from China: levels, dietary intake, and risk assessment.
- L. Zhang, Jingguang Li, +4 authors Yongning Wu
- Biology, Medicine
- Journal of agricultural and food chemistry
- 20 June 2013
Health risk assessment ofPBDEs using a MOE approach recommended by EFSA suggested unlikely health concern with respect to current dietary intake of PBDEs in China. Expand