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A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
It is reported here that human METTL14 catalyzes m6A RNA methylation, and together with METTL3, the only previously known m 6A methyltransferase, these two proteins form a stable heterodimer core complex ofMETTL3-14 that functions in cellular m6 a deposition on mammalian nuclear RNAs. Expand
Targeting BTK with ibrutinib in relapsed or refractory mantle-cell lymphoma.
Ibrutinib shows durable single-agent efficacy in relapsed or refractory mantle-cell lymphoma and is enrolled into two groups: patients who had previously received at least 2 cycles of bortezomib therapy and those who had received less than 2 complete cycles. Expand
Base-Resolution Analysis of 5-Hydroxymethylcytosine in the Mammalian Genome
Application of Tet-assisted bisulfite sequencing to embryonic stem cells not only confirms widespread distribution of 5hmC in the mammalian genome but also reveals sequence bias and strand asymmetry at5hmC sites. Expand
Return Reversals, Idiosyncratic Risk, and Expected Returns
The empirical evidence on the cross-sectional relation between idiosyncratic risk and expected stock returns is mixed. We demonstrate that the omission of the previous month's stock returns can leadExpand
Hippocampal synaptic plasticity is impaired in the Mecp2-null mouse model of Rett syndrome
Together, these data provide the first evidence that the loss of Mecp2 expression is accompanied by age-dependent alterations in excitatory synaptic plasticity that are likely to contribute to the cognitive and functional deficits underlying Rett syndrome. Expand
Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth.
Inhibition of PGAM1 by shRNA or a small molecule inhibitor PGMI-004A results in increased 3-PG and decreased 2-PG levels in cancer cells, leading to significantly decreased glycolysis, PPP flux and biosynthesis, as well as attenuated cell proliferation and tumor growth. Expand
Regulation of Planar Cell Polarity by Smurf Ubiquitin Ligases
It is shown that Smurfs engage in a noncanonical Wnt signaling pathway that targets the core PCP protein Prickle1 for ubiquitin-mediated degradation. Expand
Satellite-based entanglement distribution over 1200 kilometers
Satellite-based distribution of entangled photon pairs to two locations separated by 1203 kilometers on Earth, through two satellite-to-ground downlinks is demonstrated, with a survival of two-photon entanglement and a violation of Bell inequality. Expand
Microarray-based gene expression profiles in multiple tissues of the domesticated silkworm, Bombyx mori
A genome-wide microarray was designed and constructed with 22,987 70-mer oligonucleotides covering the presently known and predicted genes in the silkworm genome, and surveyed the gene expression in multiple silkworm tissues on day 3 of the fifth instar. Expand
Systematic identification of C. elegans miRISC proteins, miRNAs, and mRNA targets by their interactions with GW182 proteins AIN-1 and AIN-2.
It is shown that GW182 family proteins Ain-1 and AIN-2 act redundantly to regulate the expression of miRNA targets, but not miRNA biogenesis. Expand