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Five novel mono-tetrahydrofuran ring acetogenins from the seeds of Annona muricata.
TLDR
Bioactivity-directed fractionation of the seeds of Annona muricata L. (Annonaceae) resulted in the isolation of five new compounds, three of which are among the first cis mono-tetrahydrofuran ring acetogenins to be reported. Expand
Five new monotetrahydrofuran ring acetogenins from the leaves of Annona muricata.
TLDR
Bioactivity-directed fractionation of the leaves of Annona muricata resulted in the isolation of annopentocins A, B, and C(3), and cis- and trans-annomuricin-D-ones (4, 5), and new mono-THF ring acetogenins bearing two flanking hydroxyls and an erythro-diol located between the THF and the ketolactone rings. Expand
Recent advances in Annonaceous acetogenins.
TLDR
Hough most acetogenins have high potencies among several solid human tumour cells lines, some of the derivatives within the different structural types and some positional isomers show remarkable selectivities among certain cell lines, e.g. against prostate cancer (PC-3). Expand
Two new cytotoxic monotetrahydrofuran Annonaceous acetogenins, annomuricins A and B, from the leaves of Annona muricata.
TLDR
The leaves of Annona muricata have yielded eight monotetrahydrofuran Annonaceous acetogenins; two of them, annomuricins A and B, are novel and unusual. Expand
Screening for Annonaceous acetogenins in bioactive plant extracts by liquid chromatography/mass spectrometry.
TLDR
The Annonaceous acetogenins are amenable to analysis by liquid chromatography/mass spectrometry (LC/MS) using the electrospray positive-ion mode and can be readily detected by analyzing selected ion chromatograms. Expand
Two new mono-tetrahydrofuran ring acetogenins, annomuricin E and muricapentocin, from the leaves of Annona muricata.
TLDR
Both 1 and 2 showed significant cytotoxicities against six types of human tumors, with selectivities to the pancreatic carcinoma and colon adenocarcinoma cell lines. Expand
Additional bioactive acetogenins, annomutacin and (2,4-trans and cis)-10R-annonacin-A-ones, from the leaves of Annona muricata.
TLDR
Three novel monotetrahydrofuran Annonaceous acetogenins, namely, annomutacin, (2,4-trans)-10R-annonacin-A-one [2], and (2-4-cis)- 10R- annonacin -A- one [3], have been identified and showed selective cytotoxicities against the human A-549 lung tumor cell line. Expand
Muricatocins A and B, two new bioactive monotetrahydrofuran Annonaceous acetogenins from the leaves of Annona muricata.
TLDR
The leaves of Annona muricata have yielded the novel monotetrahydrofuran Annonaceous acetogenins, muricatocins A and B, which suggested relative stereochemistry and significantly enhanced cytotoxicity against the A-549 human lung tumor cell line. Expand
Bioactive compounds from Taiwania cryptomerioides.
TLDR
Bioactivities of the isolated compounds against brine shrimp, yellow fever mosquito larvae, and human tumor cells are reported; compound 4 was the most bioactive, showing selectivity for the human colon tumor cell line (HT-29). Expand
New bioactive monotetrahydrofuran Annonaceous acetogenins, annomuricin C and muricatocin C, from the leaves of Annona muricata.
TLDR
The leaves of Annona muricata have yielded two additional monotetrahydrofuran Annonaceous acetogenins, annomuricin C and muricatocin C, which suggested relative stereochemistry and significantly enhanced the cytotoxicities against the A-549 human lung and the MCF-7 human beast solid tumor cell lines. Expand
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