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Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease.
It is shown that IL-22 protected mice from IBD, and Interestingly, not only was this protection mediated by CD4+ T cells, but IL- 22-expressing natural killer (NK) cells also conferred protection. Expand
IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine
It is described that IL-22BP has a crucial role in controlling tumorigenesis and epithelial cell proliferation in the colon in steady-state conditions and the IL- 22–IL-22 BP axis critically regulates intestinal tissue repair and tumorsigenesis in the Colon. Expand
Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation.
Evidence is provided that during inflammation, IL-22 played a protective role in preventing tissue injury and interleukin-17, which is coexpressed withIL-22 and can induce similar cellular responses, had no observable role in liver inflammation. Expand
Cutting Edge: CD4 and CD8 T Cells Are Intrinsically Different in Their Proliferative Responses1
The results suggest that CD4 and CD8 T cells are programmed to undergo limited and extensive proliferation, respectively, to suit their function as regulator and effector cells. Expand
Anti-inflammatory and pro-inflammatory roles of TGF-beta, IL-10, and IL-22 in immunity and autoimmunity.
A large number of studies have highlighted the importance of regulatory cytokines in controlling the differentiation and function of lymphocytes under steady-state and inflammatory conditions, as well as minimizing tissue damage. Expand
CD4 T-cell differentiation and inflammatory bowel disease.
New studies highlight the importance of the recently identified Th17 subset in IBD, and Therapeutics targeting these aberrant Th responses are already under development and hold promise for treating IBD and other chronic inflammatory diseases. Expand
Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense.
CD103(+)CD11b(+) LPDCs, in addition to promoting long-term tolerance to ingested antigens, also rapidly produce IL-23 in response to detection of flagellin in the lamina propria. Expand
Innate and adaptive immune responses to Listeria monocytogenes: a short overview.
The Gram-positive facultative intracellular bacterium Listeria monocytogenes is a model pathogen for elucidating important mechanisms of the immune response. Infection of mice with a sub-lethal doseExpand
Synergy in a medicinal plant: antimicrobial action of berberine potentiated by 5'-methoxyhydnocarpin, a multidrug pump inhibitor.
The level of accumulation of berberine in the cells was increased strongly in the presence of 5'-MHC, indicating that this plant compound effectively disabled the bacterial resistance mechanism against the berberines antimicrobial. Expand
Recent advances in IL-22 biology.
IL-22 is known to be expressed in many chronic inflammatory conditions, including psoriasis and rheumatoid arthritis, and its up-regulation often correlates with disease activity. Expand