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Generation of high-titer defective HSV-1 vectors using an IE 2 deletion mutant and quantitative study of expression in cultured cortical cells.
Vectors based on herpes simplex virus type 1 (HSV-1) show promise for gene transfer into mammalian cells because of their wide host range, efficient infection and ability to deliver genes toExpand
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Helper virus-free transfer of herpes simplex virus type 1 plasmid vectors into neural cells.
Herpes simplex virus type 1 (HSV-1) plasmid vectors have promise for genetic intervention in the brain, but several problems caused by the helper virus have compromised their utility. To develop aExpand
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Long-term persistence of defective HSV-1 vectors in the rat brain is demonstrated by reactivation of vector gene expression.
Wild-type HSV-1 is known to persist indefinitely in neurons in the latent state; however, defective HSV-1 vectors, or amplicons, contain only approximately 1% of the HSV-1 genome and persistence ofExpand
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Use of defective herpes-derived plasmid vectors.
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Competition Between Transcription Factors and Histones, and the Role of the Histone H3 Amino Terminus, During Gene Regulation in Budding Yeast
DNA in eukaryotes is packaged into chromatin by association with the four histone proteins, H2A, H2B, H3, and H4, to form nucleosomes. Transcription factors must recognize particular DNA sequences toExpand
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