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Direct activation of RIP3/MLKL-dependent necrosis by herpes simplex virus 1 (HSV-1) protein ICP6 triggers host antiviral defense
- X. Wang, Y. Li, +16 authors S. He
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 14 October 2014
Significance Receptor-interacting kinase-3 (RIP3) and its substrate mixed lineage kinase domain-like protein (MLKL) are now recognized as the core cellular regulators of programmed necrosis.… Expand
The SCN1A Mutation Database: Updating Information and Analysis of the Relationships among Genotype, Functional Alteration, and Phenotype
Mutations in the SCN1A gene have been identified in epilepsy patients with widely variable phenotypes and modes of inheritance and in asymptomatic carriers. This raises challenges in evaluating the… Expand
A Strand-Specific RNA–Seq Analysis of the Transcriptome of the Typhoid Bacillus Salmonella Typhi
High-density, strand-specific cDNA sequencing (ssRNA–seq) was used to analyze the transcriptome of Salmonella enterica serovar Typhi (S. Typhi). By mapping sequence data to the entire S. Typhi… Expand
Metals and organochlorine pesticides in caudal scutes of crocodiles from Belize and Costa Rica.
- T. R. Rainwater, T. H. Wu, +9 authors S. Mcmurry
- Medicine, Chemistry
- The Science of the total environment
- 1 February 2007
Despite high animal diversity in the Neotropics and the largely unregulated use and disposal of pesticides and industrial chemicals in Central America, few data exist regarding accumulation of… Expand
Subinhibitory Concentrations of Thymol Reduce Enterotoxins A and B and α-Hemolysin Production in Staphylococcus aureus Isolates
Background Targeting bacterial virulence factors is now gaining interest as an alternative strategy to develop new types of anti-infective agents. It has been shown that thymol, when used at low… Expand
Phenolic composition and nutraceutical properties of organic and conventional cinnamon and peppermint.
Conventional and organic cinnamon and peppermint were investigated for their phenolic profile, anti-proliferative, anti-inflammatory, and antioxidant properties. Accelerated solvent extraction with… Expand
Perchlorate in water, soil, vegetation, and rodents collected from the Las Vegas Wash, Nevada, USA.
Water, soil, vegetation, and rodents were collected from three areas along the Las Vegas Wash, a watershed heavily contaminated with perchlorate. Perchlorate was detected at elevated concentrations… Expand
Collaborative User Network Embedding for Social Recommender Systems
Research reported in this publication was partially supported by the US Institute of Museum and Library Services (IMLS) National Leadership Grant #LG-81-16-0025, and the King Abdullah University of… Expand
Genome analysis and characterization of zinc efflux systems of a highly zinc-resistant bacterium, Comamonas testosteroni S44.
A novel and multiple metal(loid)-resistant strain Comamonas testosteroni S44 with a high Zn(2+) resistance level (10 mM) was isolated. To understand the molecular basis for the high zinc resistance,… Expand
Ligustilide ameliorates neuroinflammation and brain injury in focal cerebral ischemia/reperfusion rats: involvement of inhibition of TLR4/peroxiredoxin 6 signaling.
Blocking TLR4/peroxiredoxin (Prx6) signaling is proposed to be a novel therapeutic strategy for ischemic stroke because extracellular Prx6 released from ischemic cells may act as an endogenous ligand… Expand