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In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease
- Anna Wieckowska, N. Zein, L. Yerian, A. R. Lopez, A. Mccullough, A. Feldstein
- 1 July 2006
In patients with nonalcoholic fatty liver disease (NAFLD), a liver biopsy remains the only reliable way to differentiate simple steatosis from nonalcoholic steatohepatitis (NASH). Noninvasive methods… Expand
Severe NAFLD with hepatic necroinflammatory changes in mice fed trans fats and a high-fructose corn syrup equivalent.
- Laura H. Tetri, M. Başaranoǧlu, E. Brunt, L. Yerian, B. Neuschwander-Tetri
- Biology, Medicine
- American journal of physiology. Gastrointestinal…
- 1 November 2008
The aims of this study were to determine whether combining features of a western lifestyle in mice with trans fats in a high-fat diet, high-fructose corn syrup in the water, and interventions… Expand
Consensus statements for management of Barrett's dysplasia and early-stage esophageal adenocarcinoma, based on a Delphi process.
BACKGROUND & AIMS Esophageal adenocarcinoma (EA) is increasingly common among patients with Barrett's esophagus (BE). We aimed to provide consensus recommendations based on the medical literature… Expand
Pentoxifylline improves nonalcoholic steatohepatitis: A randomized placebo‐controlled trial
The primary aim of this study was to compare the effects of pentoxifylline (PTX) versus placebo on the histological features of nonalcoholic steatohepatitis (NASH). In all, 55 adults with… Expand
Triglyceride Levels and Not Adipokine Concentrations Are Closely Related to Severity of Nonalcoholic Fatty Liver Disease in an Obesity Surgery Cohort
Although nonalcoholic fatty liver disease (NAFLD) is frequent in obesity, the metabolic determinants of advanced liver disease remain unclear. Adipokines reflect inflammation and insulin resistance… Expand
Neutrophil to lymphocyte ratio: a new marker for predicting steatohepatitis and fibrosis in patients with nonalcoholic fatty liver disease
- N. Alkhouri, G. Morris-Stiff, +5 authors A. Feldstein
- Liver international : official journal of the…
- 1 February 2012
Nonalcoholic steatohepatitis (NASH), the most severe form of nonalcoholic fatty liver disease (NAFLD), is associated with inflammation and increased oxidative stress. The neutrophil/lymphocyte ratio… Expand
Double-blind Randomized Placebo-controlled Clinical Trial of Omega 3 Fatty Acids for the Treatment of Diabetic Patients With Nonalcoholic Steatohepatitis
- S. Dasarathy, Jaividhya Dasarathy, +4 authors A. Mccullough
- Journal of clinical gastroenterology
- 1 February 2015
Background: Nonalcoholic steatohepatitis (NASH) is common and severe in patients with diabetes mellitus. Although, there are no effective treatments for NASH in diabetic patients, preliminary reports… Expand
Risk factors for progression of low-grade dysplasia in patients with Barrett's esophagus.
BACKGROUND & AIMS Data vary on the progression of low-grade dysplasia (LGD) in patients with Barrett's esophagus (BE); in patients with LGD, we investigated the incidence of high-grade dysplasia… Expand
Cytokeratin 18 fragment levels as a noninvasive biomarker for nonalcoholic steatohepatitis in bariatric surgery patients.
- Dima L. Diab, L. Yerian, +4 authors A. Feldstein
- Clinical gastroenterology and hepatology : the…
- 1 November 2008
BACKGROUND & AIMS Nonalcoholic fatty liver disease (NAFLD) is extremely common among morbidly obese patients. We assessed the usefulness of plasma caspase-generated cytokeratin 18 (CK-18) fragments… Expand
The significance of metabolic syndrome in the setting of recurrent hepatitis C after liver transplantation
- I. Hanouneh, A. Feldstein, +5 authors N. Zein
- Liver transplantation : official publication of…
- 1 September 2008
Although hyperinsulinemia and its associated metabolic syndrome (MS) have been implicated in the progression of hepatic fibrosis in hepatitis C virus (HCV) patients, little is known about the… Expand