Author pages are created from data sourced from our academic publisher partnerships and public sources.
- Publications
- Influence
Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis
- K. Yamaguchi, L. Yang, +7 authors A. Diehl
- Medicine
- Hepatology
- 1 June 2007
In the early stages of nonalcoholic fatty liver disease (NAFLD), triglycerides accumulate in hepatocytes. Diacylglycerol acyltransferase 2 (DGAT2) catalyzes the final step in hepatocyte triglyceride… Expand
NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis.
- R. Bataller, R. Schwabe, +8 authors D. Brenner
- Biology, Medicine
- The Journal of clinical investigation
- 1 November 2003
Angiotensin II (Ang II) is a pro-oxidant and fibrogenic cytokine. We investigated the role of NADPH oxidase in Ang II-induced effects in hepatic stellate cells (HSCs), a fibrogenic cell type. Human… Expand
Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans.
- A. Omenetti, A. Porrello, +12 authors A. Diehl
- Biology, Medicine
- The Journal of clinical investigation
- 1 October 2008
Epithelial-mesenchymal transitions (EMTs) play an important role in tissue construction during embryogenesis, and evidence suggests that this process may also help to remodel some adult tissues after… Expand
Hormone-independent Transcriptional Activation and Coactivator Binding by Novel Orphan Nuclear Receptor ERR3*
- H. Hong, L. Yang, M. Stallcup
- Medicine, Biology
- The Journal of Biological Chemistry
- 6 August 1999
Orphan nuclear receptors share sequence homology with members of the nuclear receptor superfamily, but ligands are unknown or unnecessary. A novel orphan receptor, estrogen receptor-related protein 3… Expand
Prolonged infusion of angiotensin II into normal rats induces stellate cell activation and proinflammatory events in liver.
- R. Bataller, E. Gaebele, +5 authors R. Rippe
- Biology, Medicine
- American journal of physiology. Gastrointestinal…
- 1 September 2003
Recent evidence indicates that angiotensin II (ANG II) plays an important role in liver fibrogenesis. However, the underlying mechanisms are largely unknown. In advanced chronic liver diseases,… Expand
Systemic infusion of angiotensin II exacerbates liver fibrosis in bile duct–ligated rats
- R. Bataller, E. Gaebele, +5 authors R. Rippe
- Medicine
- Hepatology
- 1 May 2005
Recent evidence indicates that the renin–angiotensin system (RAS) plays a major role in liver fibrosis. Here, we investigate whether the circulatory RAS, which is frequently activated in patients… Expand
DNase I–hypersensitive sites enhance α1(I) collagen gene expression in hepatic stellate cells
- Yutaka Yata, A. Scanga, +5 authors R. Rippe
- Biology, Medicine
- Hepatology
- 1 February 2003
Liver fibrosis is characterized by a dramatic increase in the expression of type I collagen. Several deoxyribonuclease (DNase) I–hypersensitive sites (HS) have been located in the distal 5′‐flanking… Expand
A dual reporter gene transgenic mouse demonstrates heterogeneity in hepatic fibrogenic cell populations
- S. Magness, R. Bataller, L. Yang, D. Brenner
- Biology, Medicine
- Hepatology
- 1 November 2004
Activation of hepatic stellate cells (HSCs) and other resident mesenchymal cells into myofibroblasts expressing alpha smooth muscle actin (αSMA) and collagen I is a key event in liver fibrogenesis.… Expand
Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis.
- S. Choi, A. Omenetti, +9 authors A. Diehl
- Biology, Medicine
- American journal of physiology. Gastrointestinal…
- 8 October 2009
Myofibroblastic hepatic stellate cells (MF-HSC) are derived from quiescent hepatic stellate cells (Q-HSC). Q-HSC express certain epithelial cell markers and have been reported to form junctional… Expand
Vascular endothelial growth factor promotes fibrosis resolution and repair in mice.
- L. Yang, Junghee Kwon, +8 authors V. Shah
- Biology, Medicine
- Gastroenterology
- 1 May 2014
BACKGROUND & AIMS
Vascular endothelial growth factor (VEGF)-induced angiogenesis is implicated in fibrogenesis and portal hypertension. However, the function of VEGF in fibrosis resolution has not… Expand