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MicroRNA-21 Promotes Proliferation of Fibroblast-Like Synoviocytes through Mediation of NF-κB Nuclear Translocation in a Rat Model of Collagen-Induced Rheumatoid Arthritis
MicroRNA-21 (miR-21) is overexpressed in patients with rheumatoid arthritis (RA). This study was designed to investigate the effect and mechanism of miR-21 on cell proliferation in fibroblast-likeExpand
BRCA germline mutations in an unselected nationwide cohort of Chinese patients with ovarian cancer and healthy controls.
OBJECTIVE To investigate the BRCA status in Chinese patients with ovarian cancer (OC). Though there were two large prevalence studies in Chinese OC patients, this was the first time to observe it inExpand
Impact of the preoperative prognostic nutritional index on survival outcomes in upper tract urothelial carcinomas
To investigate the value of prognostic nutritional index (PNI) in patients with upper tract urothelial carcinoma (UTUC) who underwent radical nephroureterectomy (RNU).
Epalrestat protects against diabetic peripheral neuropathy by alleviating oxidative stress and inhibiting polyol pathway
Epalrestat is a noncompetitive and reversible aldose reductase inhibitor used for the treatment of diabetic neuropathy. This study assumed that epalrestat had a protective effect on diabeticExpand
Integrated aquaculture contributes to the transfer of mcr-1 between animals and humans via the aquaculture supply chain.
BACKGROUND Since its discovery in 2015, the mobile colistin resistance gene mcr-1 has been reported in bacteria from >50 countries. Although aquaculture-associated bacteria may act as a significantExpand
Breed Differences in Pig Liver Esterase (PLE) between Tongcheng (Chinese Local Breed) and Large White Pigs
Human carboxylesterases has been proven to be age and race-related and a sound basis of clinical medication. PLE involve in signal transduction and highly catalyze hydrolysis. Therefore, theExpand
Hemodynamic responses during induction: comparison of Marsh and Schnider pharmacokinetic models.
BACKGROUND Hemodynamic stability is one of the most critical concerns during induction of anesthesia. Whether the pharmacokinetic model by Marsh or the one by Schnider will produce better hemodynamicExpand
Astrocyte activation and memory impairment in the repetitive febrile seizures model
Frequently repetitive febrile seizures (FRFS) in immature brain could impair long-term memory without obvious pathological alteration. Although astrocyte activation has been implicated in manyExpand
GABBR1 gene polymorphism(G1465A)isassociated with temporal lobe epilepsy
PURPOSE γ-Aminobutyric acid B receptor 1(GABBR1) gene G1465A polymorphism has been considered as a potential risk factor for the development of temporal lobe epilepsy (TLE). However, the results wereExpand
Mutation analysis of the WNT4 gene in Han Chinese women with premature ovarian failure
BackgroundThe WNT4 gene plays an important role in female sex determination and differentiation. It also contributes to maintaining of the ovaries and the survival of follicles.MethodsWe sequencedExpand