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Actions of chiriquitoxin on frog skeletal muscle fibers and implications for the tetrodotoxin/saxitoxin receptor
Chiriquitoxin from the Costa Rican frog Atelopus chiriquensis differs from tetrodoxin (TTX) only in that a glycine residue replaces a methylene hydrogen of the C-11 hydroxymethyl function, which slows the activation of the fast potassium current in approximately 40% of the muscle fiber population.
Actions of decarbamoyloxysaxitoxin and decarbamoylneosaxitoxin on the frog skeletal muscle fiber.
11-Oxo-tetrodotoxin and a specifically labelled 3H-tetrodotoxin.
Epileptogenesis following neocortical trauma from two sources of disinhibition.
Results demonstrate that the seizure-like activity developing in deep dendrotomized cortical segments resulted from two sources of GABAergic disinhibition: the physical removal of important superficial inhibitory circuits and glutamate-triggered increases in intracellular calcium.
Adaptation of inner medullary collecting duct vacuolar H-adenosine triphosphatase to chronic acid or alkali loads in the rat.
The results indicate that translocation of the H-ATPase pump between cytoplasmic vesicles and apical plasma membrane of the intercalated cells is an important mechanism is adaptation of the IMCD to chronic acid base perturbations.
Actions of 6-epitetrodotoxin and 11-deoxytetrodotoxin on the frog skeletal muscle fiber.
Valproate Prevents Epileptiform Activity After Trauma in an In Vitro Model in Neocortical Slices
Valproate significantly reduces epileptiform activity after trauma to the neocortex, likely by restoring the excitation-inhibition balance, perhaps through augmentation of gamma-aminobutyric acid transmission.
Acetylcholine, Ca2+ overload and oscillatory potentials in isolated ventricular myocytes.
The effects of Ca overload are antagonized by ACh in the absence and presence of sympathetic enhancement, and the mechanism underlying Ios appears to involve an electrogenic Ca extrusion and not an increase in a nonspecific conductance.