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Molecular cloning of mevalonate kinase and regulation of its mRNA levels in rat liver.
Data indicate that long-term regulation of enzyme activity in rat liver is controlled by changes in the levels of mevalonate kinase mRNA, and shows sequence homology to the yeast RAR1 protein. Expand
Estrogen sulfatase and estrogen sulfotransferase in human primary mammary carcinoma.
The results imply that the circulating estrogen sulfate could be utilized as the precursor of active estrogen to promote the cell growth in hormone sensitive tumors. Expand
Estrogen sulfotransferase in human placenta.
Kinetic studies using partially purified ESFT revealed that E2 is the best substrate for this enzyme, and was abolished by isoelectrofocusing but partially retained by chromatofocusing. Expand
Identification of inducible damage-recognition proteins that are overexpressed in HeLa cells resistant to cis-diamminedichloroplatinum (II).
The results suggest that the damage-recognition proteins are regulated in the cells in response to DNA damage, and they may be important for DNA repair and probably the emergence of cisplatin resistance. Expand
Nucleotide sequence of the rat low density lipoprotein receptor cDNA.
Purification and regulation of mevalonate kinase from rat liver.
Under experimental conditions, mevalonate kinase activity in the liver was regulated principally by changes in the rates of enzyme synthesis and degradation. Expand