• Publications
  • Influence
Analysis of Drosophila Segmentation Network Identifies a JNK Pathway Factor Overexpressed in Kidney Cancer
We constructed a large-scale functional network model in Drosophila melanogaster built around two key transcription factors involved in the process of embryonic segmentation. Analysis of the modelExpand
  • 108
  • 9
  • PDF
Tumor suppressor CYLD regulates JNK-induced cell death in Drosophila.
CYLD encodes a tumor suppressor that is mutated in familial cylindromatosis. Despite biochemical and cell culture studies, the physiological functions of CYLD in animal development and tumorigenesisExpand
  • 93
  • 7
  • PDF
NOPO modulates Egr-induced JNK-independent cell death in Drosophila
Tumor necrosis factor (TNF) family ligands play essential roles in regulating a variety of cellular processes including proliferation, differentiation and survival. Expression of Drosophila TNFExpand
  • 49
  • 7
  • PDF
Downregulation of miR-486-5p contributes to tumor progression and metastasis by targeting protumorigenic ARHGAP5 in lung cancer
We have previously shown that miR-486-5p is one of the most downregulated micro RNAs in lung cancer. The objective of the study was to investigate the role of miR-486-5p in the progression andExpand
  • 167
  • 5
14-3-3σ regulates keratinocyte proliferation and differentiation by modulating Yap1 cellular localization
The homozygous repeated epilation (Er/Er) mouse mutant of the gene encoding 14-3-3σ displays an epidermal phenotype characterized by hyperproliferative keratinocytes and undifferentiated epidermis.Expand
  • 26
  • 5
Toll pathway modulates TNF-induced JNK-dependent cell death in Drosophila
Signalling networks that control the life or death of a cell are of central interest in modern biology. While the defined roles of the c-Jun N-terminal kinase (JNK) pathway in regulating cell deathExpand
  • 36
  • 4
  • PDF
Loss of flfl Triggers JNK-Dependent Cell Death in Drosophila
  • J. Huang, L. Xue
  • Biology, Medicine
  • BioMed research international
  • 25 October 2015
falafel (flfl) encodes a Drosophila homolog of human SMEK whose in vivo functions remain elusive. In this study, we performed gain-of-function and loss-of-function analysis in Drosophila andExpand
  • 9
  • 3
  • PDF
Berberine ameliorates diabetic nephropathy by inhibiting TLR4/NF-κB pathway
BackgroundDiabetic nephropathy (DN) is the leading cause of end-stage renal failure, contributing to severe morbidity and mortality in diabetic patients. Berberine (BBR) has been well characterizedExpand
  • 37
  • 2
Aging might augment reactive oxygen species (ROS) formation and affect reactive nitrogen species (RNS) level after myocardial ischemia/reperfusion in both humans and rats
Previous studies indicate aging results in significantly decreased cardiac function and increased myocardial apoptosis after myocardial ischemia/reperfusion (MI/R) in humans or rats. The underlyingExpand
  • 56
  • 2
ROBO3 promotes growth and metastasis of pancreatic carcinoma.
Pancreatic carcinoma is a highly lethal malignancy with an extremely poor prognosis. Recent genome-wide studies have implicated axon guidance pathways, including the SLIT/ROBO pathway, in pancreaticExpand
  • 20
  • 2