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Average gene length is highly conserved in prokaryotes and eukaryotes and diverges only between the two kingdoms.
TLDR
The average length of genes in a eukaryote is larger than in a prokaryote, implying that evolution of complexity is related to change of gene lengths, and natural selection has clearly set a strong limitation on gene elongation within the kingdom. Expand
Biotransformation of N-ethyl-N-(2-hydroxyethyl)perfluorooctanesulfonamide by rat liver microsomes, cytosol, and slices and by expressed rat and human cytochromes P450.
TLDR
Results show that the major pathway for the biotransformation of N-EtFOSE is N-dealkylation to give FOSA, which explains the observation that PFOS is found in animals given N-eTFOSE. Expand
Therapeutic targets and limits of minocycline neuroprotection in experimental ischemic stroke
TLDR
The data indicate that the neuroprotection is dose-dependent, in that only low dose minocycline inhibits neuronal cell death cascades at the acute stroke phase, whereas the high dose exacerbates the ischemic injury. Expand
Conserved and Novel Functions for Arabidopsis thaliana MIA40 in Assembly of Proteins in Mitochondria and Peroxisomes
TLDR
The mechanistic operation of the mitochondrial disulfide relay system is different in A. thaliana compared with other systems, and Mia40 has taken on new roles in peroxisomes and mitochondria. Expand
Biosynthesis of (S)-4-chloro-3-hydroxybutanoate ethyl using Escherichia coli co-expressing a novel NADH-dependent carbonyl reductase and a glucose dehydrogenase.
TLDR
A novel NADH-dependent carbonyl reductase (PsCR II) gene with an open reading frame of 855bp encoding 285 amino acids was cloned from Pichia stipitis and revealed less than 55% identity to known reductases that produce (S)-4-chloro-3-hydroxybutanoates ethyl [(S)-CHBE]. Expand
Detection and characterization of diverse alpha- and betacoronaviruses from bats in China
TLDR
Two new species of bat CoV, identified through sequence comparison and phylogenetic analysis, are proposed, with a wide distribution in China. Expand
N-GLUCURONIDATION OF PERFLUOROOCTANESULFONAMIDE BY HUMAN, RAT, DOG, AND MONKEY LIVER MICROSOMES AND BY EXPRESSED RAT AND HUMAN UDP-GLUCURONOSYLTRANSFERASES
TLDR
The kinetics of N-glucuronidation of FOSA by rat liver microsomes and by hUGT2B4/7 was consistent with a single-enzyme Michaelis-Menten model, whereas human livermicrosomes showed sigmoidal kinetics. Expand
Production of fibrinolytic enzyme from Bacillus amyloliquefaciens by fermentation of chickpeas, with the evaluation of the anticoagulant and antioxidant properties of chickpeas.
TLDR
This study provided a novel method for the preparation of multifunctional food of chickpeas or raw materials for the Preparation of functional food additives and potential drugs. Expand
A complete protein pattern of cellulase and hemicellulase genes in the filamentous fungus Trichoderma reesei.
TLDR
The complete protein pattern of cellulase and hemicellulase genes was studied through the Genome-wide analysis in Trichoderma reesei and four groups were created and analyzed by phylogenetic analysis, in which 8 beta-glucosidases appeared to be non-secreted proteins. Expand
Altererythrobacter atlanticus sp. nov., isolated from deep-sea sediment.
TLDR
On the basis of phenotypic and genotypic data, strain 26DY36(T), isolated from a deep-sea sediment sample collected from the North Atlantic Rise, represents a novel species of the genus Altererythrobacter, for which the name AltereRYthrobacteria atlanticus sp. Expand
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