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Investigating the Metabolic Changes due to Visual Stimulation using Functional Proton Magnetic Resonance Spectroscopy at 7 T
Proton magnetic resonance spectroscopy (1H-MRS) has been used to demonstrate metabolic changes in the visual cortex on visual stimulation. Small (2% to 11%) but significant stimulation inducedExpand
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Net increase of lactate and glutamate concentration in activated human visual cortex detected with magnetic resonance spectroscopy at 7 tesla
After the landmark studies reporting changes in the cerebral metabolic rate of glucose (CMRGlc) in excess of those in oxygen (CMRO2) during physiological stimulation, several studies have examinedExpand
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1H NMR spectroscopy of rat brain in vivo at 14.1Tesla: improvements in quantification of the neurochemical profile.
Ultra-short echo-time proton single voxel spectra of rat brain were obtained on a 14.1T 26 cm horizontal bore system. At this field, the fitted linewidth in the brain tissue of adult rats was aboutExpand
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Are glutamate and lactate increases ubiquitous to physiological activation? A 1H functional MR spectroscopy study during motor activation in human brain at 7Tesla
We extend functional MR spectroscopy (fMRS) to investigate for the first time the metabolite changes during motor activation at 7T. Expand
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N-acetylcysteine in a Double-Blind Randomized Placebo-Controlled Trial: Toward Biomarker-Guided Treatment in Early Psychosis
Abstract Biomarker-guided treatments are needed in psychiatry, and previous data suggest oxidative stress may be a target in schizophrenia. A previous add-on trial with the antioxidantExpand
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Is the macromolecule signal tissue‐specific in healthy human brain? A 1H MRS study at 7 tesla in the occipital lobe
The macromolecule signal plays a key role in the precision and the accuracy of the metabolite quantification in short‐TE 1H MR spectroscopy. Macromolecules have been reported at 1.5 Tesla (T) toExpand
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Glutathione deficit impairs myelin maturation: relevance for white matter integrity in schizophrenia patients
Schizophrenia pathophysiology implies both abnormal redox control and dysconnectivity of the prefrontal cortex, partly related to oligodendrocyte and myelin impairments. As oligodendrocytes areExpand
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Proton T2 relaxation time of J‐coupled cerebral metabolites in rat brain at 9.4 T
Knowledge of proton T2 relaxation time of metabolites is essential for proper quantitation of metabolite concentrations in localized proton spectroscopy, especially at moderate to long TEs. AlthoughExpand
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Genetic Polymorphism Associated Prefrontal Glutathione and Its Coupling With Brain Glutamate and Peripheral Redox Status in Early Psychosis.
BACKGROUND Oxidative stress and glutathione (GSH) metabolism dysregulation has been implicated in the pathophysiology of schizophrenia. GAG-trinucleotide repeat (TNR) polymorphisms in theExpand
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Comparison of T1 relaxation times of the neurochemical profile in rat brain at 9.4 tesla and 14.1 tesla
Knowledge of T1 relaxation times can be important for accurate relative and absolute quantification of brain metabolites, for sensitivity optimizations, for characterizing molecular dynamics, and forExpand
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