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GPIIIa-(49-66) is a major pathophysiologically relevant antigenic determinant for anti-platelet GPIIIa of HIV-1-related immunologic thrombocytopenia.
- M. Nardi, L. X. Liu, S. Karpatkin
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 8 July 1997
HIV-1-ITP patients have high-affinity anti-platelet GPIIIa against a major antigenic determinant, GP IIIa-(49-66), which correlates inversely with platelet count and induces thrombocytopenia in mice. Expand
Inhibition of binding of anti-PLA1 antibodies to platelets with monoclonal antibody LK-4. Evidence for multiple PLA1 receptor sites on platelet GPIIIa.
The PLA1 epitope on platelet GPIIIa has a sulfhydryl-dependent conformation and is dependent on a leucine 33/proline33 polymorphism. Monoclonal antibody LK-4 differentiates PLA1/PLA1 from PLA2/PLA2… Expand
A 13-mer peptide straddling the leucine33/proline33 polymorphism in glycoprotein IIIa does not define the PLA1 epitope.
The PLA1 epitope is conformation-induced, resides on an N-terminal 55-Kd fragment composed of two or more peptides held together by -SH bonds, and is not required for platelet aggregation. Expand
Production of a human anti-CD4 monoclonal antibody with antiidiotype to anti-HIV type 1 glycoprotein 120.
- S. Karpatkin, M. Nardi, L. X. Liu, Y. Kouri, W. Borkowsky
- Biology, Medicine
- AIDS research and human retroviruses
- 1 April 1995
The production of a human monoclonal antiidiotype antibody that inhibits binding of HIV-1 to CD4 and induces the production of antibody against anti-HIV-1 gp120 is indicated, without being an internal image antiidiotsype (Ab2 beta). Expand
Effects of alkylated-chitosan–DNA nanoparticles on the function of macrophages
- L. X. Liu, C. Song, L. Song, H. Zhang, X. Dong, X. Leng
- Materials Science, Medicine
- Journal of materials science. Materials in…
- 1 April 2009
The results demonstrated that the alkylated-chitosan/DNA nanoparticles at the concentration of 20 μg/ml DNA content had no significant impact on the production of cytokines and phagocytic activity of the macrophages as compared with the unmodified chitOSan/ DNA nanoparticles and negative control even after 24 h co-incubation. Expand
A monoclonal antibody (LK-4) which differentiates PLA1 from PLA2 platelet extracts but not intact platelets.
It is suggested the LK-4 reacts with a conformation-induced common epitope for PLA1 and PLA2 on GP IIIa, with loss of this conformation for PLA2 GPIIIa following solubilization with Triton X-100. Expand
PP-154 Effects of Alzet mini-osmotic pumps controlled release of IGFBPrP1 on liver and lung in mice
PP-036 Dynamic changes of both IGFBPrP1 and transforming growth factorâ1/Smad on liver tissue with fibrosis in mice
IGP1 was involved in the formation and development of hepatic fibrosis and this function of IGFBPrP1 probably relates to promote activation of HSC; promote the synthesis and secretion of both collagenI and FN; affect TGFβ1/Smad3 pathway. Expand
OL-082 Effect of SiRNA-mediated Smad3 silence on proliferation and apoptosis in activated hepatic stellate cells