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Defective Lymphotoxin-β Receptor-Induced NF-κB Transcriptional Activity in NIK-Deficient Mice
The role of NF-κB–inducing kinase (NIK) in cytokine signaling remains controversial. To identify the physiologic functions of NIK, we disrupted the NIK locus by gene targeting. Although NIK–/– miceExpand
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Bile acid metabolites control Th17 and Treg cell differentiation
Bile acids are abundantly present in the mammalian gut, where they undergo bacteria-mediated transformation, generating a large pool of bioactive molecules. While they have been shown to affect hostExpand
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NDRG2 in rat liver regeneration: Role in proliferation and apoptosis
  • J. Yang, Y. Li, +9 authors Kefeng Dou
  • Biology, Medicine
  • Wound repair and regeneration : official…
  • 1 September 2010
Liver regeneration is a complex process that is orchestrated by the precise interplay of cell proliferation, differentiation control, and molecular pathways, but this complicated molecular signalingExpand
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Long-term survival benefit of ruxolitinib in a patient with relapsed refractory chronic active Epstein–Barr virus
Dear Editor, Chronic active Epstein–Barr virus (CAEBV) often succumbs to hemophagocytic lymphohistiocytosis, multi-organ failure, or Epstein–Barr virus–positive lymphomas if untreated. The onlyExpand
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Sympathetic nervous system promotes hepatocarcinogenesis by modulating inflammation through activation of alpha1-adrenergic receptors of Kupffer cells
The sympathetic nervous system (SNS) is known to play a significant role in tumor initiation and metastasis. Hepatocellular carcinoma (HCC) frequently occurs in cirrhotic livers after chronicExpand
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Essential roles of 11β-HSD1 in regulating brown adipocyte function.
Brown adipose tissue (BAT) increases energy expenditure and is an attractive therapeutic target for obesity. 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1), an amplifier of local glucocorticoidExpand
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Detection of EGFR-activating mutations from plasma DNA as a potent predictor of survival outcomes in FASTACT 2: A randomized phase III study on intercalated combination of erlotinib (E) and
8021 Background: Biomarker analysis of tumor from FASTACT 2 confirmed predictive power of EGFR mut on the benefit of intercalated combination of E and C as 1st line in advanced NSCLC (T. Mok, ESMOExpand
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A phase I study of MDM2 antagonist RG7112 in patients (pts) with relapsed/refractory solid tumors.
e13600^ Background: RG7112 is a small molecule MDM2 antagonist, designed to non-genotoxically activate p53. A phase I dose escalation (DE) was performed, followed by a sarcoma biomarker extensionExpand
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USP16 Downregulation by Carboxyl-terminal Truncated HBx Promotes the Growth of Hepatocellular Carcinoma Cells
Hepatitis B virus (HBV) infection is a major factor that contributes to the development of hepatocellular carcinoma (HCC). HBV X protein (HBx) has been shown to accelerate HCC progression byExpand
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Ginsenoside Rb1 Reverses H2O2-induced Senescence in Human Umbilical Endothelial Cells: Involvement of eNOS Pathway
Objective Senescence of endothelial cells has been implicated in endothelial dysfunction and atherogenesis. This study investigated the effects of Rb1, a major ginsenoside in ginseng, on H2O2-inducedExpand
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